Academic Journal
Fortgeschrittenes NSCLC: Prognostisches Modell für Langzeitüberlebende mit EGFR-Mutation
| العنوان: | Fortgeschrittenes NSCLC: Prognostisches Modell für Langzeitüberlebende mit EGFR-Mutation |
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| المؤلفون: | Horter, Susanne, Schütte, Wolfgang |
| المصدر: | Kompass Pneumologie ; volume 10, issue 1, page 24-25 ; ISSN 2296-0368 2296-0317 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2021 |
| الوصف: | Background: There is a lack of useful diagnostic tools to identify EGFR mutated NSCLC patients with long-term survival. This study develops a prognostic model using real world data to assist clinicians to predict survival beyond 24 months. Methods: EGFR mutated stage IIIB and IV NSCLC patients diagnosed between January 2009 and December 2017 included in the Spanish Lung Cancer Group (SLCG) thoracic tumor registry. Long-term survival was defined as being alive 24 months after diagnosis. A multivariable prognostic model was carried out using binary logistic regression and internal validation through bootstrapping. A nomogram was developed to facilitate the interpretation and applicability of the model. Results: 505 of the 961 EGFR mutated patients identified in the registry were included, with a median survival of 27.73 months. Factors associated with overall survival longer than 24 months were: being a woman (OR 1.78); absence of the exon 20 insertion mutation (OR 2.77); functional status (ECOG 0–1) (OR 4.92); absence of central nervous system metastases (OR 2.22), absence of liver metastases (OR 1.90) or adrenal involvement (OR 2.35) and low number of metastatic sites (OR 1.22). The model had a good internal validation with a calibration slope equal to 0.781 and discrimination (optimism corrected C-index 0.680). Conclusions: Survival greater than 24 months can be predicted from six pre-treatment clinicopathological variables. The model has a good discrimination ability. We hypothesized that this model could help the selection of the best treatment sequence in EGFR mutation NSCLC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000520849 |
| الاتاحة: | http://dx.doi.org/10.1159/000520849 https://www.karger.com/Article/Pdf/520849 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.58A197A6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000520849 |
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