أعرض في EDS

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

التفاصيل البيبلوغرافية
العنوان: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
المؤلفون: Shah T, Thiery J, Giral P, Lind L, Wilson JF, Franco OH, Smit AJ, Sitzer M, Campbell H, Strawbridge RJ, Winkler TW, Volzke H, Nalls MA, Lyytikainen LP, Schminke U, Galesloot TE, Evans MK, Veglia F, de Vries PS, Price J, van Duijn CM, Wassel CL, Heckbert SR, Rotter JI, Loeffler M, Lehtimaki T, Markus HS, Pott J, O'Leary DH, Kurl S, Launer LJ, Mannarino E, Isaacs A, Hwang SJ, Lu LY, Zonderman AB, Humphries SE, Sargurupremraj M, Grossi E, Graff M, de Faire U, Newman AB, Saba Y, Post W, Liang JJ, Hofman A, Bis JC, Morris RW, Penninx BW, O'Donnell CJ, Schmidt H, Snieder H, Dichgans M, Kavousi M, Heiss G, Anugu P, Nolte IM, Uitterlinden AG, Schadt EE, Volker U, Wardlaw JM, Kuh D, Gertow K, Joshi PK, Tzourio C, Taylor KD, Langefeld CD, Amouyel P, Deanfield J, Ingelsson E, Zhu XF, Rice K, Holdt LM, Teupser D, Engmann J, Hagg S, Schmidt R, Whincup PH, Roussos P, Tremoli E, Kumari M, Zhang XL, Dhana K, McLachlan S, Marioni RE, Plagnol V, Boerwinkle E, Pitkanen N, Raitakari O, Rivadeneira F, Franzen O, Kivimaki M, Tajuddin SM, Hamsten A, Jukema JW, Seldenrijk A, Dorr M, Wilson JG, Finan C, Melander O, Correa A, Psaty BM, Wannamethee SG, Hopewell JC, Fava C, Beutner F, Franceschini N, Guo XQ, Rosamond WD, Harris TB, Giambartolomei C, Wong A, Chauhan G, Lawlor DA, de Mutsert R, Cox AJ, Pasaniuc B, Halcox J, Kiemeney LALM, Traylor M, Hingorani AD, Casas JP, Britton A, Noordam R, de Graaf J, Dale C, Baldassarre D, Raffield LM, Ruusalepp A, Wong Q, Deary IJ, Lovering RC, Mook-Kanamori DO, Dehghan A, Trompet S, Sennblad B, Bjorkegren JLM, Rauramaa R, Shah S, Teumer A, Hardy R, Burkhardt R, Morrison AC, Scholz M, Seshadri S, Debette S, Palmas W, Rueda-Ochoa OL, Hedblad B, Ring S, Bowden DW, Hofer E, Huntley RP, Malik R, Musani SK, Gudnason V, Smith AV, van Leeuwen EM
المساهمون: sydäntutkimuskeskus, Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), tyks, vsshp, tyks, vsshp, 2607004
بيانات النشر: NATURE PUBLISHING GROUP
United Kingdom
Britannia
GB
سنة النشر: 2022
المجموعة: University of Turku: UTUPub / Turun yliopisto
الوصف: Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
نوع الوثيقة: other/unknown material
اللغة: English
تدمد: 2041-1723
Relation: ARTN 5141; Nature Communications; https://www.utupub.fi/handle/10024/167788; URN:NBN:fi-fe2021042720504
الاتاحة: https://www.utupub.fi/handle/10024/167788
رقم الانضمام: edsbas.5899D889
قاعدة البيانات: BASE
الوصف
تدمد:20411723