التفاصيل البيبلوغرافية
| العنوان: |
Magnetothermally Triggered Free-Radical Generation for Deep-Seated Tumor Treatment |
| المؤلفون: |
Guoming Huang (1534435), Yuan Qiu (405709), Feifei Yang (334047), Jiangao Xie (10479611), Xin Chen (14149), Lili Wang (104605), Huanghao Yang (1761655) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Pharmacology, Cancer, Space Science, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, novel magnetothermodynamic strategy, cancer cells, tumor treatment, PHION, Magnetothermally Triggered Free-Rad., magnetothermodynamic therapy strategy, iron oxide nanoparticles, penetration depth, photodynamic therapy, hypoxic conditions, rat model, AMF, alkyl radicals, oxygen independence, tissue penetration limitation, Deep-Seated Tumor Treatment Tumor h., oxygen-independent alkyl radicals, tumor therapy, orthotopic liver tumors, AIPH, excitation light, penetration depth limitation, free-radical generator exhibits |
| الوصف: |
Tumor hypoxia and the tissue penetration limitation of excitation light hamper the widespread clinical use of photodynamic therapy. The development of new therapeutic strategies that can generate oxygen-independent free radicals without penetration depth limitation is of great demand. Herein, a novel magnetothermodynamic strategy for deep-seated tumor therapy is reported. In this system, a radical initiator (AIPH) was loaded into porous hollow iron oxide nanoparticles (PHIONs). Under the induction of an alternating magnetic field (AMF), PHIONs can generate heat to trigger the release and decomposition of AIPH, resulting in the generation of oxygen-independent alkyl radicals. The resulting alkyl radicals can effectively kill cancer cells under hypoxic conditions. More importantly, this magnetothermally triggered free-radical generator exhibits significant therapeutic efficacy for orthotopic liver tumors in a rat model. This magnetothermodynamic therapy strategy with the advantages of oxygen independence and no limitation of penetration depth holds great promise in deep-seated solid tumor treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Magnetothermally_Triggered_Free-Radical_Generation_for_Deep-Seated_Tumor_Treatment/14327171 |
| DOI: |
10.1021/acs.nanolett.1c00009.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.nanolett.1c00009.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.587344 |
| قاعدة البيانات: |
BASE |