Academic Journal
Composites consisting of poly(methyl methacrylate) and alumina powder: An evaluation of their mechanical and biological properties
| العنوان: | Composites consisting of poly(methyl methacrylate) and alumina powder: An evaluation of their mechanical and biological properties |
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| المؤلفون: | Shinzato, Shuichi, Nakamura, Takashi, Kokubo, Tadashi, Kitamura, Yoshiro |
| المصدر: | Journal of Biomedical Materials Research ; volume 60, issue 4, page 585-591 ; ISSN 0021-9304 1097-4636 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2002 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | We developed new composites consisting of comparatively high molecular weight poly(methyl methacrylate) (hPMMA) and δ‐alumina powder or α‐alumina powder (designated δ‐APC and α‐APC, respectively) that allowed direct bone formation on their surfaces in vivo . δ‐Alumina powder was manufactured by the fusing and quenching of pulverized alumina powder. It was composed mainly of δ‐crystal phases of alumina. The purpose of this study was to evaluate the static mechanical properties and biological properties of these composites. The hPMMA itself was used as a reference material. The bending strength and Young's modulus of both δ‐APC and α‐APC were significantly higher than those of hPMMA, and the alumina composites are believed to be strong enough for use under weight‐bearing conditions. The three types of composites were packed into the intramedullary canals of rat tibiae to evaluate osteoconductivity, as determined by an affinity index. Rats were sacrificed 4 and 8 weeks after surgery. The affinity index, equal to the length of bone in direct contact with the composite surface and expressed as a percentage of the total length of the composite surface, was calculated for each composite at each interval. Histologically, new bone had formed along the surfaces of both δ‐APC and α‐APC within 4 weeks. The affinity indices for both δ‐APC and α‐APC increased significantly with time up to 8 weeks. At 8 weeks, the affinity index for δ‐APC was significantly higher than the indices for α‐APC and hPMMA. This study revealed that the excellent osteoconductivity of δ‐APC was due to the δ‐crystal phases of alumina and the high molecular weight of hPMMA. δ‐APC shows promise as a base for developing a highly osteoconductive and mechanically strong biomaterial. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 585–591, 2002 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jbm.10104 |
| الاتاحة: | http://dx.doi.org/10.1002/jbm.10104 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbm.10104 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.10104 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.58326C6C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jbm.10104 |
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