Academic Journal
Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration
| العنوان: | Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration |
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| المؤلفون: | Yuekun Fang, Jie Hu, Yang Zou, Zhichen Wang, Yuchen Ye, Changchun Zhang |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Genetics, Physiology, Ecology, Developmental Biology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, vivo assessment showed, large pore size, enhanced survival space, degenerated intervertebral disks, intervertebral disk repair, oxidative stress process, neochlorogenic acid combined, ncg effectively inhibited, repair process, neochlorogenic acid, oxidative microenvironment, unknown etiology, tissue engineering, model groups, important method, common disease, apoptosis rate, apoptosis caused |
| الوصف: | Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by the oxidative microenvironment. Herein, bone marrow mesenchymal stem cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into a GelMA hydrogel as a carrier to protect transplanted stem cells. Ncg effectively inhibited the oxidative stress process and reduced the apoptosis rate. A 5% GelMA hydrogel had a large pore size and porosity that provided an enhanced survival space for cells. An in vivo assessment showed that treatment with GelMA + BMSC + Ncg produced greater repair of degenerated intervertebral disks than that found in other model groups. Thus, this study may help contribute to improving stem cell transplantation for treating intervertebral disk degeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Neochlorogenic_Acid_Combined_with_Bone_Marrow_Mesenchymal_Stem_Cells_Encapsulated_into_GelMA_Hydrogel_for_Transplantation_to_Repair_Intervertebral_Disk_Degeneration/25052802 |
| DOI: | 10.1021/acs.biomac.3c00923.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.biomac.3c00923.s001 https://figshare.com/articles/journal_contribution/Neochlorogenic_Acid_Combined_with_Bone_Marrow_Mesenchymal_Stem_Cells_Encapsulated_into_GelMA_Hydrogel_for_Transplantation_to_Repair_Intervertebral_Disk_Degeneration/25052802 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.5809F92F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.biomac.3c00923.s001 |
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