Academic Journal
Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1
| العنوان: | Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1 |
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| المؤلفون: | Alemasova, Elizaveta, Pestryakov, Pavel, Sukhanova, Maria, Kretov, Dmitry, Moor, Nina, Curmi, Patrick, A., Ovchinnikov, Lev, Lavrik, Olga |
| المساهمون: | Institute of Chemical Biology and Fundamental Medicine Novosibirsk, Russia (ICBFM SB RAS), Siberian Branch of the Russian Academy of Sciences (SB RAS), Université d'État de Novossibirsk, Institute of Protein Research, Russian Academy of Sciences, Pushchino, Structure et activité des biomolécules normales et pathologiques (SABNP), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0300-9084. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | AP endonuclease 1 (APE1), Multiple DNA lesions, Poly(ADP-ribose) (PAR, Poly(ADP-ribose)polymerase 1 (PARP1), Y-box binding protein 1 (YB-1), pADPr), [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Multifunctional Y-box binding protein 1 (YB-1) is actively studied as one of the components of cellular response to genotoxic stress. However, the precise role of YB-1 in the process of DNA repair is still obscure. In the present work we report for the first time new posttranslational modification of YB-1 - poly(ADP-ribosyl)ation, catalyzed by one of the main regulatory enzymes of DNA repair - poly(ADP-ribose)polymerase 1 (PARP1) in the presence of model DNA substrate carrying multiple DNA lesions. Therefore, poly(ADP-ribosyl)ation of YB-1 catalyzed with PARP1, can be stimulated by damaged DNA. The observed property of YB-1 underlines its ability to participate in the DNA repair by its involvement in the regulatory cascades of DNA repair. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.biochi.2015.10.008 |
| الاتاحة: | https://univ-evry.hal.science/hal-02272805 https://doi.org/10.1016/j.biochi.2015.10.008 |
| رقم الانضمام: | edsbas.57F2231B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.biochi.2015.10.008 |
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