التفاصيل البيبلوغرافية
| العنوان: |
Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report. |
| المؤلفون: |
Yrondi, A., Vaiva, Guillaume, Walter, M., D Amato, T., Bellivier, F., Bennabi, D., Bougerol, T., Camus, V., Doumy, O., Genty, J. B., Haffen, E., Holtzmann, J., Horn, Mathilde, Lançon, C., Leboyer, M., Llorca, P. M., Maruani, J., Moirand, R., Molière, F., Petrucci, J., Richieri, R., Samalin, L., Schmitt, L., Stephan, F. |
| المساهمون: |
Université de Lille, Inserm, CHU Lille, Fondation FondaMental Créteil, Lille Neurosciences & Cognition (LilNCog) - U 1172, CHRU Brest - Psychiatrie Adulte CHU - Brest- Psychiatrie |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2024 |
| المجموعة: |
LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: |
Childhood trauma, Childhood abuse, Childhood neglect, Treatment-resistant depression, Suicide, Depressive disorders |
| الوصف: |
Objective In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations. Methods Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively. Results Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect: β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores. Conclusion We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population. ; 135 |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/octet-stream |
| اللغة: |
English |
| Relation: |
Journal of Psychiatric Research; J Psychiatr Res; http://hdl.handle.net/20.500.12210/110567 |
| الاتاحة: |
https://hdl.handle.net/20.500.12210/110567 |
| رقم الانضمام: |
edsbas.57C1F319 |
| قاعدة البيانات: |
BASE |