Academic Journal
Animal multicellularity and polarity without Wnt signaling
| العنوان: | Animal multicellularity and polarity without Wnt signaling |
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| المؤلفون: | Schenkelaars, Quentin, Pratlong, Marine, Kodjabachian, Laurent, Fierro-Constain, Laura, Vacelet, Jean, Le Bivic, André, Renard, Emmanuelle, Borchiellini, Carole |
| المساهمون: | Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement IRD : UMR237-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | Université d'Avignon et des Pays de Vaucluse: HAL |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
| الوصف: | International audience ; Acquisition of multicellularity is a central event in the evolution of Eukaryota. Strikingly, animal multicellularity coincides with the emergence of three intercellular communication pathways – Notch, TGF-β and Wnt – all considered as hallmarks of metazoan development. By investigating Oopsacas minuta and Aphrocallistes vastus, we show here that the emergence of a syncytium and plugged junctions in glass sponges coincides with the loss of essential components of the Wnt signaling (i.e. Wntless, Wnt ligands and Disheveled), whereas core components of the TGF-β and Notch modules appear unaffected. This suggests that Wnt signaling is not essential for cell differentiation, polarity and morphogenesis in glass sponges. Beyond providing a comparative study of key developmental toolkits, we define here the first case of a metazoan phylum that maintained a level of complexity similar to its relatives despite molecular degeneration of Wnt pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-01680462; https://hal.science/hal-01680462; https://hal.science/hal-01680462/document; https://hal.science/hal-01680462/file/Schenkelaars%20et%20al.,%202017%20SR.pdf |
| DOI: | 10.1038/s41598-017-15557-5 |
| الاتاحة: | https://hal.science/hal-01680462 https://hal.science/hal-01680462/document https://hal.science/hal-01680462/file/Schenkelaars%20et%20al.,%202017%20SR.pdf https://doi.org/10.1038/s41598-017-15557-5 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.57B34D87 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-017-15557-5 |
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