Academic Journal

Plant Poly(ADP-Ribose) Polymerase 1 Is a Potential Mediator of Cross-Talk between the Cajal Body Protein Coilin and Salicylic Acid-Mediated Antiviral Defence

التفاصيل البيبلوغرافية
العنوان: Plant Poly(ADP-Ribose) Polymerase 1 Is a Potential Mediator of Cross-Talk between the Cajal Body Protein Coilin and Salicylic Acid-Mediated Antiviral Defence
المؤلفون: Nadezhda Spechenkova, Viktoriya O. Samarskaya, Natalya O. Kalinina, Sergey K. Zavriev, S. MacFarlane, Andrew J. Love, Michael Taliansky
المصدر: Viruses; Volume 15; Issue 6; Pages: 1282
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2023
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: poly ADP-ribosylation (PARylation), nucleolus, Cajal bodies, tobacco rattle virus, PARP inhibitor, salicylic acid
جغرافية الموضوع: agris
الوصف: The nucleolus and Cajal bodies (CBs) are sub-nuclear domains with well-known roles in RNA metabolism and RNA-protein assembly. However, they also participate in other important aspects of cell functioning. This study uncovers a previously unrecognised mechanism by which these bodies and their components regulate host defences against pathogen attack. We show that the CB protein coilin interacts with poly(ADP-ribose) polymerase 1 (PARP1), redistributes it to the nucleolus and modifies its function, and that these events are accompanied by substantial increases in endogenous concentrations of salicylic acid (SA), activation of SA-responsive gene expression and callose deposition leading to the restriction of tobacco rattle virus (TRV) systemic infection. Consistent with this, we also find that treatment with SA subverts the negative effect of the pharmacological PARP inhibitor 3-aminobenzamide (3AB) on plant recovery from TRV infection. Our results suggest that PARP1 could act as a key molecular actuator in the regulatory network which integrates coilin activities as a stress sensor for virus infection and SA-mediated antivirus defence.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Viruses of Plants, Fungi and Protozoa; https://dx.doi.org/10.3390/v15061282
DOI: 10.3390/v15061282
الاتاحة: https://doi.org/10.3390/v15061282
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.578EF3E2
قاعدة البيانات: BASE