Academic Journal
Management of adult patients with CMML undergoing allo-HCT: recommendations from the EBMT PH&G Committee
| العنوان: | Management of adult patients with CMML undergoing allo-HCT: recommendations from the EBMT PH&G Committee |
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| المؤلفون: | Onida, Francesco, Gagelmann, Nico, Chalandon, Yves, Kobbe, Guido, Robin, Marie, Symeonidis, Argiris, de Witte, Theo M., Itzykson, Raphaël A., Jentzsch, Madlen, Platzbecker, Uwe, Santini, Valeria, Sanz, Guillermo F., Scheid, Christoph, Solary, Eric, Valent, Peter, Greco, Raffaela, Sánchez-Ortega, Isabel, Yakoub-Agha, Ibrahim, Pleyer, Lisa |
| المساهمون: | F. Onida, N. Gagelmann, Y. Chalandon, G. Kobbe, M. Robin, A. Symeonidi, T.M. de Witte, R.A. Itzykson, M. Jentzsch, U. Platzbecker, V. Santini, G.F. Sanz, C. Scheid, E. Solary, P. Valent, R. Greco, I. Sánchez-Ortega, I. Yakoub-Agha, L. Pleyer |
| بيانات النشر: | American Society of Hematology |
| سنة النشر: | 2024 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | CMML, allo-HCT, EBMT, Settore MED/15 - Malattie del Sangue, Settore MED/06 - Oncologia Medica |
| الوصف: | Chronic myelomonocytic leukemia (CMML) is a heterogeneous disease presenting with either myeloproliferative or myelodysplastic features. Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only potentially curative option, but the inherent toxicity of this procedure makes the decision to proceed to allo-HCT challenging, particularly as patients with CMML are mostly older and comorbid. Therefore, the decision between a non-intensive treatment approach and allo-HCT represents a delicate balance, especially since prospective randomized studies are lacking and retrospective data in the literature is conflicting. International consensus on the selection of patients and the ideal timing of allo-HCT specifically in CMML could not be reached in international recommendations published six years ago. Since then, new, CMML-specific data have been published. The European Society for Blood and Marrow Transplantation (EBMT) Practice Harmonization and Guidelines Committee assembled a panel of experts in the field to provide the first best practice recommendations on the role of allo-HCT specifically in CMML. Recommendations were based on the results of an international survey, a comprehensive review of the literature, and expert opinions on the subject, after structured discussion and circulation of recommendations. Algorithms for patient selection, timing of allo-HCT during the course of the disease, pre-transplant strategies, allo-HCT modality, as well as post-transplant management for patients with CMML were outlined. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38493484; info:eu-repo/semantics/altIdentifier/wos/WOS:001249307300001; firstpage:1; lastpage:43; numberofpages:43; journal:BLOOD; https://hdl.handle.net/2434/1042855; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85191436056 |
| DOI: | 10.1182/blood.2023023476 |
| الاتاحة: | https://hdl.handle.net/2434/1042855 https://doi.org/10.1182/blood.2023023476 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.578D641E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood.2023023476 |
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