Academic Journal
Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism
| العنوان: | Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism |
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| المؤلفون: | Pérez Arana, Gonzalo Martín, Almorza Gomar, David, Mayo Ossorio, María de los Ángeles, Camacho Ramírez, Alonso, Castro Santiago, María Jesús, Valverde Martínez, Amparo, Casado Maestre, María Dolores, Visiedo García, Francisco Manuel, Bohórquez Sierra, Juan Carlos, Prada Oliveira, José Arturo |
| المساهمون: | Anatomía y Embriología Humana, Cirugía |
| المصدر: | J Gastrointest surg. 2024 apr; 28 (4):381-388 |
| بيانات النشر: | Journal of Gastrointestinal Surgery |
| سنة النشر: | 2024 |
| المجموعة: | RODIN - Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| مصطلحات موضوعية: | Gastrin, Sleeve gastrectomy, Beta-cell mass, Bariatric surgery |
| الوصف: | Background Among bariatric techniques, sleeve gastrectomy (SG) stands out owing to its efficiency. The role of the stomach as a secretory organ of many substances, such as gastrin, related to insulin secretion is well known. Gastrin induces insulin release in isolated pancreatic islets, limiting somatostatin-14 intraislet release, and has been associated with blood glucose level improvement in diabetic models after SG. SG involves gastric resection along the greater curvature. This study aimed to determine the role of gastrin in glucose metabolism improvement after SG with the aid of the gastrin antagonist netazepide. Methods In 12 sham-operated, 12 SG-operated, and 12 SG-operated/netazepide-treated Wistar rats, we compared medium- and long-term plasma insulin, oral glucose tolerance test (OGTT) results, and plasma gastrin levels. In addition, gastrin expression was assessed in the gastric remnant, and the beta-cell mass was measured. Results SG induced a medium-term elevation of the insulin response and plasma gastrin levels without modification of the OGTT results. However, long-term depletion of the insulin response with elevated OGTT areas under the curve and plasma gastrin levels appeared after SG. Netazepide prevented the SG effect on these parameters. Gastrin tissue expression was greater in SG animals than in SG/netazepide-treated or control animals. The beta-cell mass was lower in the SG group than in the control or SG/netazepide group. Conclusion Gastrin plays a central role in glucose improvement after SG. It stimulates a medium-term strong insulin response but also causes long-term beta-cell mass depletion and a loss of insulin response. These effects are prevented by gastrin antagonists such as netazepide. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1091-255X |
| Relation: | http://hdl.handle.net/10498/31768 |
| DOI: | 10.1016/j.gassur.2024.02.015 |
| الاتاحة: | http://hdl.handle.net/10498/31768 https://doi.org/10.1016/j.gassur.2024.02.015 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; closed access |
| رقم الانضمام: | edsbas.576E3E5A |
| قاعدة البيانات: | BASE |
| تدمد: | 1091255X |
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| DOI: | 10.1016/j.gassur.2024.02.015 |