Academic Journal
Long-Term Effects of SARS-CoV-2 Infection in Hospitalized Children: Findings from an Italian Single-Center Study
| العنوان: | Long-Term Effects of SARS-CoV-2 Infection in Hospitalized Children: Findings from an Italian Single-Center Study |
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| المؤلفون: | Valeria Calcaterra, Veronica Maria Tagi, Enza D'auria, Alessia Lai, Sara Zanelli, Chiara Montanari, Elia Maria Biganzoli, Giuseppe Marano, Elisa Borghi, Valentina Massa, Agostino Riva, Gianvincenzo Zuccotti |
| المساهمون: | V. Calcaterra, V.M. Tagi, E. D'Auria, A. Lai, S. Zanelli, C. Montanari, E. Maria Biganzoli, G. Marano, E. Borghi, V. Massa, A. Riva, G. Zuccotti |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | SARS-CoV-2, Infection, COVID, Long COVID, Long-term effect, Hospitalized, Children, Settore MED/42 - Igiene Generale e Applicata, Settore MED/07 - Microbiologia e Microbiologia Clinica, Settore MED/38 - Pediatria Generale e Specialistica, Settore MED/17 - Malattie Infettive |
| الوصف: | Background Limited evidence exists regarding the association between COVID-19 and Long COVID manifestations in children, particularly concerning variants of concern (VOCs). We aimed to characterize a cohort of pediatric patients hospitalized with confirmed acute SARS-CoV-2 and monitor them for Long COVID symptoms. Additionally, it seeks to explore any potential correlations between VOCs and clinical symptoms. Methods We conducted a prospective study involving children hospitalized from November 2021 to March 2023, with confirmed acute SARS-CoV-2 infection. A telephone survey was conducted at 3-6-12 months after discharge. Results We included 167 patients (77 F/90 M). Upon hospital admission, 95.5% of patients presented as symptomatic. Regarding patients for whom it was feasible to determine the SARS-CoV-2 variant (n = 51), the Delta variant was identified in 11 children (21.6%) and Omicron variant in the remaining 40 patients (78.4%: 27.5% BA.1 variant; 15% BA.2 variant; 57.5% BA.5 variant). 19 patients (16.5%) reported experiencing at least one symptom indicative of Long COVID (weight loss 31.6%, inappetence 26.3%, chronic cough 21.1%, fatigue 21.1%, and sleep disturbances, wheezing, abdominal pain and mood disorders 15.8%). In only 4 patients with Long COVID we could identified a specific SARS- CoV-2 variant (3 Omicron: 2 BA.1 and 1 BA.2; 1 Delta). Conclusions this study underscores that long COVID is a significant concern in the pediatric population. Our data reinforce the importance of continuously monitoring the impact of long-COVID in infants, children, and adolescents. A follow-up following SARS-CoV-2 infection is therefore advisable, with symptom investigation tailored to the patient’s age. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001162674200004; volume:50; firstpage:1; lastpage:9; numberofpages:9; journal:THE ITALIAN JOURNAL OF PEDIATRICS; https://hdl.handle.net/2434/1025745; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85185096250 |
| DOI: | 10.1186/s13052-024-01596-y |
| الاتاحة: | https://hdl.handle.net/2434/1025745 https://doi.org/10.1186/s13052-024-01596-y |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.575DDF7B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13052-024-01596-y |
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