Academic Journal
Regional Differences in Clinical Presentation and Prognosis of Patients With Post-Sustained Virologic Response Hepatocellular Carcinoma.
| العنوان: | Regional Differences in Clinical Presentation and Prognosis of Patients With Post-Sustained Virologic Response Hepatocellular Carcinoma. |
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| المؤلفون: | Toyoda, Hidenori, Kanneganti, Mounika, Melendez-Torres, Jonathan, Parikh, Neehar D, Jalal, Prasun K, Piñero, Federico, Mendizabal, Manuel, Ridruejo, Ezequiel, Cheinquer, Hugo, Casadei-Gardini, Andrea, Weinmann, Arndt, Peck-Radosavljevic, Markus, Dufour, Jean-Francois, Radu, Pompilia, Shiha, Gamal, Soliman, Riham, Sarin, Shiv K, Kumar, Manoj, Wang, Jing-Houng, Tangkijvanich, Pisit, Sukeepaisarnjaroen, Wattana, Atsukawa, Masanori, Uojima, Haruki, Nozaki, Akito, Nakamuta, Makoto, Takaguchi, Koichi, Hiraoka, Atsushi, Abe, Hiroshi, Matsuura, Kentaro, Watanabe, Tsunamasa, Shimada, Noritomo, Tsuji, Kunihiko, Ishikawa, Toru, Mikami, Shigeru, Itobayashi, Ei, Singal, Amit G, Johnson, Philip J |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2024 |
| المجموعة: | The University of Liverpool Repository |
| الوصف: | Background & aims Widespread use of direct-acting antivirals for hepatitis C virus infection has been paralleled with increased numbers of patients with hepatocellular carcinoma (HCC) after achieving sustained virologic response (post-SVR HCC) worldwide. Few data compare regional differences in the presentation and prognosis of patients with post-SVR HCC. Methods We identified patients with advanced fibrosis (F3/F4) who developed incident post-SVR HCC between March 2015 and October 2021 from 30 sites in Europe, North America, South America, the Middle East, South Asia, East Asia, and Southeast Asia. We compared patient demographics, liver dysfunction, and tumor burden by region. We compared overall survival by region using Kaplan-Meier analysis and identified factors associated with survival using multivariable Cox regression analysis. Results Among 8796 patients with advanced fibrosis or cirrhosis who achieved SVR, 583 (6.6%) developed incident HCC. There was marked regional variation in the proportion of patients detected by surveillance (range: 59.5%-100%), median maximum tumor diameter (range, 1.8-5.0 cm), and the proportion with multinodular HCC (range, 15.4%-60.8%). The prognosis of patients highly varied by region (hazard ratio range, 1.82-9.92), with the highest survival rates in East Asia, North America, and South America, and the lowest survival rates in the Middle East and South Asia. After adjusting for geographic region, HCC surveillance was associated with early stage detection (Barcelona Clinic Liver Cancer stage 0/A, 71.0% vs 21.3%; P < .0001) and lower mortality rates (adjusted hazard ratio, 0.29; 95% CI, 0.18-0.46). Conclusions Clinical characteristics, including early stage detection, and prognosis of post-SVR HCC differed significantly across geographic regions. Surveillance utilization appears to be a high-yield intervention target to improve prognosis among patients with post-SVR HCC globally. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://livrepository.liverpool.ac.uk/3171832/3/CGH.pdf; Collapse authors list. Toyoda, Hidenori orcid:0000-0002-1652-6168 , Kanneganti, Mounika, Melendez-Torres, Jonathan, Parikh, Neehar D orcid:0000-0002-5874-9933 , Jalal, Prasun K orcid:0000-0001-5353-2324 , Piñero, Federico, Mendizabal, Manuel, Ridruejo, Ezequiel, Cheinquer, Hugo, Casadei-Gardini, Andrea orcid:0000-0001-6289-7202 et al (show 27 more authors) , Weinmann, Arndt, Peck-Radosavljevic, Markus, Dufour, Jean-Francois, Radu, Pompilia, Shiha, Gamal, Soliman, Riham, Sarin, Shiv K, Kumar, Manoj, Wang, Jing-Houng, Tangkijvanich, Pisit, Sukeepaisarnjaroen, Wattana, Atsukawa, Masanori, Uojima, Haruki, Nozaki, Akito, Nakamuta, Makoto, Takaguchi, Koichi, Hiraoka, Atsushi, Abe, Hiroshi, Matsuura, Kentaro, Watanabe, Tsunamasa, Shimada, Noritomo, Tsuji, Kunihiko, Ishikawa, Toru, Mikami, Shigeru, Itobayashi, Ei, Singal, Amit G and Johnson, Philip J orcid:0000-0003-1404-0209 (2024) Regional Differences in Clinical Presentation and Prognosis of Patients With Post-Sustained Virologic Response Hepatocellular Carcinoma. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 22 (1). 72-80.e4. |
| DOI: | 10.1016/j.cgh.2023.06.026 |
| الاتاحة: | http://livrepository.liverpool.ac.uk/3171832/ https://doi.org/10.1016/j.cgh.2023.06.026 http://livrepository.liverpool.ac.uk/3171832/3/CGH.pdf |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.5748BBFC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cgh.2023.06.026 |
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