Academic Journal

Effectiveness of a New Active Tear Substitute Containing 0.2% Hyaluronic Acid and 0.001% Hydrocortisone on Signs and Symptoms of Dry Eye Disease by Means of Low- and High-Tech Assessments

التفاصيل البيبلوغرافية
العنوان: Effectiveness of a New Active Tear Substitute Containing 0.2% Hyaluronic Acid and 0.001% Hydrocortisone on Signs and Symptoms of Dry Eye Disease by Means of Low- and High-Tech Assessments
المؤلفون: Fogagnolo, Paolo, Giannaccare, Giuseppe, Mencucci, Rita, Villani, Edoardo, Orfeo, Vincenzo, Aragona, Pasquale, De Ruvo, Valentino, Strianese, Alfonso, Quisisana, Chiara, Borselli, Massimiliano, Rossi, Costanza, Carnovale Scalzo, Giovanna, Postorino, Elisa Imelde, Azzaro, Claudia, Mercuri, Stefano, Lucarelli, Flavia, De Vitto, Chiara, Ferioli, Eleonora, Marelli, Luca, Napolitano, Pasquale, Giannì, Mario Cristian
المساهمون: P. Fogagnolo, G. Giannaccare, R. Mencucci, E. Villani, V. Orfeo, P. Aragona, V. De Ruvo, A. Strianese, C. Quisisana, M. Borselli, C. Rossi, G. Carnovale Scalzo, E.I. Postorino, C. Azzaro, S. Mercuri, F. Lucarelli, C. De Vitto, E. Ferioli, L. Marelli, P. Napolitano, M.C. Giannì
بيانات النشر: SPRINGER INT PUBL AG
سنة النشر: 2024
المجموعة: The University of Milan: Archivio Istituzionale della Ricerca (AIR)
مصطلحات موضوعية: DED, Dry eye disease, Hydrocortisone, Inflammation, Lubricating eye drop, Tear film, Settore MED/30 - Malattie Apparato Visivo
الوصف: IntroductionAn innovative eye drops formulation containing 0.2% hyaluronic acid and a low concentration of hydrocortisone (0.001%; hereafter HALH) has been recently placed on the market (Idroflog (R), Alfa Intes, Italy) to manage the dysregulated parainflammation in patients with dry eye disease (DED). In the present paper, the effectiveness of HALH on the signs and symptoms of DED was retrospectively evaluated and compared with that one obtained using standard tear substitutes (STS) by means of low- and high-tech (Keratograph (R)) assessments.MethodsThis was a multicenter retrospective study carried out between February and April 2023, involving adult patients with DED diagnosis owing to post-cataract surgery, meibomian gland dysfunction, allergy, or glaucoma medications. The primary aim was to compare the changes induced by different therapies on Keratograph (R) parameters (noninvasive Keratograph tear breakup time [NIKBUT], tear meniscus height [TMH], eyelid meibography, conjunctival hyperemia, and conjunctivochalasis) or collected by traditional low-tech measures (tear breakup time [TBUT], Schirmer test, Efron score, and epithelial alterations) and the Ocular Surface Disease Index score.ResultsData from 155 patients were analyzed. The effectiveness of HALH and STS was reported by both high- and low-tech measures. NIKBUT-first showed a significant improvement in the HALH group versus the STS one at 15 days (6.4 +/- 3.6 vs 5.4 +/- 3.7 s, p = 0.02), whereas this difference was latent with low-tech TBUT until 45 days (6.8 +/- 2.6 vs 5.6 +/- 2.3 s, p = 0.03). Patients with DED occurring after cataract surgery reported an enhanced activity of HALH versus STS, particularly for NIKBUT-first, TMH, Schirmer test, and hyperemia stage.ConclusionThese findings highlighted the effectiveness of HALH in all DED subtypes, especially in patients with post-cataract surgery, as well as its superiority versus STS in terms of tear film stability improvement. We recommend longer observation (i.e., 3-6 months) to fully ascertain ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/37948015; info:eu-repo/semantics/altIdentifier/wos/WOS:001100598400002; volume:13; issue:1; firstpage:251; lastpage:266; numberofpages:16; journal:OPHTHALMOLOGY AND THERAPY; https://hdl.handle.net/2434/1049790; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85176563932
DOI: 10.1007/s40123-023-00833-7
الاتاحة: https://hdl.handle.net/2434/1049790
https://doi.org/10.1007/s40123-023-00833-7
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.570F1FA1
قاعدة البيانات: BASE
الوصف
DOI:10.1007/s40123-023-00833-7