Academic Journal
Modulation of immune response to Lol p I by pretreatment with anti-idiotypic antibody is not restricted to the idiotypic expression
| العنوان: | Modulation of immune response to Lol p I by pretreatment with anti-idiotypic antibody is not restricted to the idiotypic expression |
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| المؤلفون: | BOUTIN, Y, HÉBERT, J |
| المصدر: | Clinical and Experimental Immunology ; volume 96, issue 2, page 350-355 ; ISSN 0009-9104 1365-2249 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | SUMMARY To study the role of anti-idiotypic antibodies in the regulation of the immune response to Lol p I (the major allergenic component of rye grass pollen), we have recently generated a panel of three MoAbs directed against distinct epitopes of Lol p I and an anti-idiotypic MoAb directed against the idiotype borne by one of the anti-Lol p I MoAbs (290A-167). The effects of pretreatment with this anti-idiotypic MoAb in BALB/c mice before immunization with the antigen have been examined. The anti-idiotypic MoAb or unrelated MoAb were given weekly for 8 weeks intraperitoneally. Mice then received the antigen (2 μg) adsorbed with alum (2 mg) at weeks 9, 11 and 13. Serum anti-Lol p I antibodies (IgG or IgE) and specific idiotypic responses were measured. Anti-Lol pI IgG antibodies could be detected before immunization with Lol p I only in mice pretreated with anti-idiotypic MoAb. Immunization with Lol p I induced an anti-Lol p I IgG response in both groups, but this response was higher in mice that received anti-idiotypic MoAb. Similar profiles were seen for specific IgE antibodies and idiotypic responses. Surprisingly, idiotypes borne by other anti-Lol p I MoAbs (539A-6 and 348A-6) had also been enhanced after pretreatment with the anti-290A-167 MoAb. These observations suggested that the pretreatment with this anti-idiotypic MoAb modulates not only the expression of the respective idiotype, but also affects other idiotype responses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-2249.1994.tb06566.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-2249.1994.tb06566.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2249.1994.tb06566.x https://academic.oup.com/cei/article-pdf/96/2/350/42210013/j.1365-2249.1994.tb06566.x.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.5701B24A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-2249.1994.tb06566.x |
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