التفاصيل البيبلوغرافية
| العنوان: |
Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats |
| المؤلفون: |
Slavik, Kenneth J., LaPointe, J. |
| المصدر: |
PCOM Scholarly Papers |
| سنة النشر: |
1993 |
| المجموعة: |
Philadelphia College of Osteopathic Medicine: DigitalCommons@PCOM |
| مصطلحات موضوعية: |
α2- adrenoceptors, autonomic nervous system, conscious, dopaminergic, indirect tail cuff, treadmill exercise conditioning, alpha 2 adrenergic receptor, bromocriptine, clonidine, dopamine 2 receptor, metoclopramide, yohimbine, animal model, article, bradycardia, controlled study, female, hypotension, nonhuman, priority journal, rat, systolic blood pressure, treadmill exercise, Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Animal, Blood Pressure, Heart Rate, Physical Conditioning, Rats |
| الوصف: |
The purpose of this investigation was to examine the underlying cause for the resting bradycardia and lower resting blood pressure demonstrated in conscious rats that performed 12 wk of treadmill exercise conditioning. The influence of inhibitory dopamine (DA2) receptors and α2-adrenoceptors, which are known to mediate bradycardia and hypotension, was assessed in exercise-conditioned (EC) and nonexercised conditioned (NC) rats. To accomplish this, preferential DA2 and α2-agonists and antagonists were administered at rest to conscious rats after they participated in an exercise conditioning program. The results obtained with the DA2 antagonist metoclopramide (15 mg/kg ip) alone suggest that there is physiological activation of cardiovascular DA2 receptors in EC rats but not in NC rats. Furthermore, the results obtained with the DA2 agonist bromocriptine (1.5 mg/kg ip) suggest that the DA2 receptor-mediated bradycardia and hypotension are greater in EC rats than in NC rats. In addition, heart rate and blood pressure responses to the α2-agonist clonidine (0.1 mg/kg ip) and antagonist yohimbine (1 mg/kg ip) were not different between EC and NC rats. These data suggest that enhanced DA2 receptor influence accounts, in part, for the resting bradycardia and lower resting blood pressure demonstrated in EC rats after 12 wk of exercise conditioning. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| Relation: |
https://digitalcommons.pcom.edu/scholarly_papers/1536 |
| الاتاحة: |
https://digitalcommons.pcom.edu/scholarly_papers/1536 |
| رقم الانضمام: |
edsbas.56F77A2A |
| قاعدة البيانات: |
BASE |