التفاصيل البيبلوغرافية
| العنوان: |
The effect of 1,2,4-triazole-3-thiol derivatives bearing hydrazone moiety on cancer cell migration and growth of melanoma, breast, and pancreatic cancer spheroids / |
| المؤلفون: |
Šermukšnytė, Aida, Kantminienė, Kristina, Jonuškienė, Ilona, Tumosienė, Ingrida, Petrikaitė, Vilma |
| المصدر: |
Pharmaceuticals., Basel : MDPI, 2022, vol. 15, iss. 8, art. no. 1026, p. 1-20. ; ISSN 1424-8247 |
| سنة النشر: |
2022 |
| المجموعة: |
KTU ePubl (Kaunas University of Technology / Kauno Technologijos Universitetas) |
| مصطلحات موضوعية: |
hydrazone, isatin, 2-oxindole, 1,2,4-triazole, melanoma, pancreatic tumor, triple-negative breast cancer, 3D tumor model, migration |
| الوصف: |
4-Phenyl-3-[2-(phenylamino)ethyl]-1H-1,2,4-triazole-5(4H)-thione was used as a starting compound for the synthesis of the corresponding 1,2,4-triazol-3-ylthioacetohydrazide, which reacts with isatins and various aldehydes bearing aromatic and heterocyclic moieties provided target hydrazones. Their cytotoxicity was tested by the MTT assay against human melanoma IGR39, human triple-negative breast cancer (MDA-MB-231), and pancreatic carcinoma (Panc-1) cell lines. The selectivity of compounds towards cancer cells was also studied. In general, the synthesized compounds were more cytotoxic against the melanoma cell line. N′-(2-oxoindolin-3-ylidene)-2-((4-phenyl-5-(2-(phenylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide, N′-((1H-pyrrol-2-yl)methylene)-2-((4-phenyl-5-(2-(phenylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide and N′-(2-hydroxy-5-nitrobenzylidene)-2-((4-phenyl-5-(2-(phenylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide were identified as the most active among all synthesized compounds in 3D cell cultures. N′-(4-(dimethylamino)benzylidene)-2-((4-phenyl-5-(2-(phenylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide inhibited all cancer cell migration, was characterized as relatively more selective towards cancer cells, and could be further tested as an antimetastatic candidate. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://epubl.ktu.edu/object/elaba:138627007/138627007.pdf; https://vb.ktu.edu/KTU:ELABAPDB138627007&prefLang=en_US |
| الاتاحة: |
https://vb.ktu.edu/KTU:ELABAPDB138627007&prefLang=en_US |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.56E6920B |
| قاعدة البيانات: |
BASE |