Academic Journal
Thrombus obliteration by rapid percutaneous endovenous intervention in deep venous occlusion (TORPEDO) trial: Midterm results
| العنوان: | Thrombus obliteration by rapid percutaneous endovenous intervention in deep venous occlusion (TORPEDO) trial: Midterm results |
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| المؤلفون: | Sharifi, Mohsen, Bay, Curt, Mehdipour, Mahshid, Sharifi, Jalaladdin |
| المصدر: | DIHS Faculty Publications |
| بيانات النشر: | Still ScholarWorks |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Anticoagulation, Percutaneous endovenous intervention, Post-thrombotic syndrome, Recurrent deep venous thrombosis, Stent, Thrombectomy, Thrombolysis, Venoplasty, Venous thromboembolism, Venous thrombolysis |
| الوصف: | Purpose: To present midterm results from a randomized study comparing the safety and efficacy of percutaneous endovenous intervention (PEVI) + anticoagulation vs. anticoagulation alone in the reduction of venous thromboembolism (VTE) and post-thrombotic syndrome (PTS) in acute symptomatic proximal deep venous thrombosis (DVT). Methods: The TORPEDO trial was a randomized study to demonstrate superiority of PEVI in the reduction of the VTE and PTS at 6 months; in that trial, 183 patients (103 men; mean age 61±11 years) with symptomatic proximal DVT were randomized to receive PEVI + anticoagulation (n=91) or anticoagulation alone (n=92). PEVI consisted of one or more of a combination of thrombectomy, balloon venoplasty, stenting, and/or local low-dose thrombolytic therapy. Results: At 6 months, recurrent VTE developed in 2.3% of the PEVI + anticoagulation group vs. 14.8% in the anticoagulation only group (p=0.003); PTS developed in 3.4% vs. 27.2% (p<0.001), respectively. At a mean follow-up of 30±5 months (range 12-41), 88 patients in the PEVI + anticoagulation group and 81 patients in the anticoagulation only group reached target follow-up. Recurrent VTE developed in 4 (4.5%) of the 88 PEVI + anticoagulation patients vs. 13 (16%) of the 81 patients receiving anticoagulation only (p=0.02). PTS developed in 6 (6.8%) of the PEVI + anticoagulation group vs. 24 (29.6%) of the anticoagulation only group (p<0.001). Conclusion: In patients with proximal DVT, PEVI is superior to anticoagulation alone in the reduction of VTE and PTS. This benefit, which appears early in the course of treatment, extends to >2.5 years. © 2012 by the International Society of Endovascular Specialists. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| DOI: | 10.1583/11-3674MR.1 |
| الاتاحة: | https://scholarworks.atsu.edu/dihs-faculty/91 https://doi.org/10.1583/11-3674MR.1 |
| رقم الانضمام: | edsbas.56D3B625 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1583/11-3674MR.1 |
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