Academic Journal
Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
| العنوان: | Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery |
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| المؤلفون: | Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor, Ostos, Francisco José, Sepúlveda, Ranier, Romero Palacios, Alberto, Rafii-El-Idrissi Benhnia, Mohamed, Chicardi, E. |
| المساهمون: | Universidad de Sevilla, Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor, Ostos, Francisco José, Sepúlveda, Ranier, Romero Palacios, Alberto, Chicardi, E. |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2023 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Degradation rate, Gelatin, Hydrogel, Infiltration, Porous titanium, Solid foams |
| الوصف: | A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated. ; The characterization studies were financed by University of Seville under project No. 2021/00000691 by the VI Research Program of the University of Seville. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-85-14-65597-8 85-14-65597-3 |
| تدمد: | 2073-4360 |
| Relation: | Publisher's version; https://doi.org/10.3390/polym15020275; Sí; Polymers 15(2): 275 (2023); http://hdl.handle.net/10261/340112; http://dx.doi.org/10.13039/100009042; 2-s2.0-85146559730; https://api.elsevier.com/content/abstract/scopus_id/85146559730 |
| DOI: | 10.3390/polym15020275 |
| DOI: | 10.13039/100009042 |
| الاتاحة: | http://hdl.handle.net/10261/340112 https://doi.org/10.3390/polym15020275 https://doi.org/10.13039/100009042 https://api.elsevier.com/content/abstract/scopus_id/85146559730 |
| Rights: | open |
| رقم الانضمام: | edsbas.56BB52EA |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9788514655978 8514655973 |
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| تدمد: | 20734360 |
| DOI: | 10.3390/polym15020275 |