Academic Journal
Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers
| العنوان: | Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers |
|---|---|
| المؤلفون: | Gonzalez-Martinez, Daniel, Fernandez-Saez, Nerea, Cativiela, Carlos, Campos, Joaquin M., Gotor-Fernandez, Vicente |
| المساهمون: | Gonzalez-Martinez, Daniel Univ Oviedo, Organ & Inorgan Chem Dept, Ave Julian Claveria 8, E-33006 Oviedo, Spain, Gotor-Fernandez, Vicente Univ Oviedo, Organ & Inorgan Chem Dept, Ave Julian Claveria 8, E-33006 Oviedo, Spain, Fernandez-Saez, Nerea Fac Farm, Dept Quim Farmaceut & Organ, C Campus Cartuja S-N, Granada 18071, Spain, Campos, Joaquin M. Fac Farm, Dept Quim Farmaceut & Organ, C Campus Cartuja S-N, Granada 18071, Spain, Cativiela, Carlos Univ Zaragoza, CSIC, ISQCH, Dept Quim Organ, E-50009 Zaragoza, Spain, Campos, Joaquin M. Univ Granada, Complejo Hosp Univ Granada, Inst Invest Biosanitaria IbsGRANADA, E-18071 Granada, Spain, Spanish Ministry of Economy and Competitiveness (MINECO), Junta de Andalucia, Gobierno de Aragon-FEDER |
| بيانات النشر: | Mdpi |
| سنة النشر: | 2018 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | amine transaminases, asymmetric synthesis, benzoxathiepins, biocatalysis, biotransamination, stereoselective synthesis, Efficient asymmetric-synthesis, Employing omega-transaminases, Optically-active amines, Imine reductases ireds, Chiral amines, 1,5-benzoxathiepin derivatives, Amination, Ketones, Reactivity |
| الوصف: | The stereoselective synthesis of chiral amines is an appealing task nowadays. In this context, biocatalysis plays a crucial role due to the straightforward conversion of prochiral and racemic ketones into enantiopure amines by means of a series of enzyme classes such as amine dehydrogenases, imine reductases, reductive aminases and amine transaminases. In particular, the stereoselective synthesis of 1,5-benzoxathiepin-3-amines have attracted particular attention since they possess remarkable biological profiles; however, their access through biocatalytic methods is unexplored. Amine transaminases are applied herein in the biotransamination of 3,4-dihydro-2H-1,5-benzoxathiepin-3-one, finding suitable enzymes for accessing both target amine enantiomers in high conversion and enantiomeric excess values. Biotransamination experiments have been analysed, trying to optimise the reaction conditions in terms of enzyme loading, temperature and reaction times. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4344 |
| Relation: | http://hdl.handle.net/10668/19253; https://www.mdpi.com/2073-4344/8/10/470/pdf?version=1539934395; 448543300066 |
| DOI: | 10.3390/catal8100470 |
| الاتاحة: | http://hdl.handle.net/10668/19253 https://doi.org/10.3390/catal8100470 https://www.mdpi.com/2073-4344/8/10/470/pdf?version=1539934395 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access |
| رقم الانضمام: | edsbas.569DE029 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734344 |
|---|---|
| DOI: | 10.3390/catal8100470 |