Academic Journal
Data-driven analysis of regional brain metabolism in behavioral frontotemporal dementia and late-onset primary psychiatric diseases with frontal lobe syndrome: A PET/MRI study
| العنوان: | Data-driven analysis of regional brain metabolism in behavioral frontotemporal dementia and late-onset primary psychiatric diseases with frontal lobe syndrome: A PET/MRI study |
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| المؤلفون: | Cagnin A., Pigato G., Pettenuzzo I., Zorzi G., Roiter B., Anglani M. G., Busse C., Mozzetta S., Gabelli C., Campi C., Cecchin D. |
| المساهمون: | Cagnin, A., Pigato, G., Pettenuzzo, I., Zorzi, G., Roiter, B., Anglani, M. G., Busse, C., Mozzetta, S., Gabelli, C., Campi, C., Cecchin, D. |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2024 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Frontotemporal dementia, Frontotemporal lobar degeneration, Metabolism, PET, Phenocopy, Psychiatric disease |
| الوصف: | Late-onset primary psychiatric disease (PPD) and behavioral frontotemporal dementia (bvFTD) present with a similar frontal lobe syndrome. We compare brain glucose metabolism in bvFTD and late-onset PPD and investigate the metabolic correlates of cognitive and behavioral disturbances through FDG-PET/MRI. We studied 37 bvFTD and 20 late-onset PPD with a mean clinical follow-up of three years. At baseline evaluation, metabolism of the dorsolateral, ventrolateral, orbitofrontal regions and caudate could classify the patients with a diagnostic accuracy of 91% (95% CI: 0.81–0.98%). 45% of PPD showed low-grade hypometabolism in the anterior cingulate and/or parietal regions. Frontal lobe metabolism was normal in 32% of genetic bvFTD and bvFTD with motor neuron signs. Hypometabolism of the frontal and caudate regions could help in distinguishing bvFTD from PPD, except in cases with motor neuron signs and/or genetic bvFTD for which brain metabolism may be less informative. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38422798; info:eu-repo/semantics/altIdentifier/wos/WOS:001199016200001; volume:137; firstpage:47; lastpage:54; numberofpages:8; journal:NEUROBIOLOGY OF AGING; https://hdl.handle.net/11577/3510475; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85186531659 |
| DOI: | 10.1016/j.neurobiolaging.2024.01.015 |
| الاتاحة: | https://hdl.handle.net/11577/3510475 https://doi.org/10.1016/j.neurobiolaging.2024.01.015 |
| رقم الانضمام: | edsbas.569CCB28 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neurobiolaging.2024.01.015 |
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