Academic Journal
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
| العنوان: | Prox2 and Runx3 vagal sensory neurons regulate esophageal motility |
|---|---|
| المؤلفون: | Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E., Birchmeier, C. |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Cancer Research, Function and Dysfunction of the Nervous System, Technology Platforms, Topic 1: Genes, Cells and Cell-Based Medicine, Topic 2: Molecular Processes and Therapies, Topic 3: Integrative Biomedicine |
| الوصف: | Vagal sensory neurons monitor mechanical and chemical stimuli in the gastrointestinal tract. Major efforts are underway to assign physiological functions to the many distinct subtypes of vagal sensory neurons. Here, we use genetically guided anatomical tracing, optogenetics, and electrophysiology to identify and characterize vagal sensory neuron subtypes expressing Prox2 and Runx3 in mice. We show that three of these neuronal subtypes innervate the esophagus and stomach in regionalized patterns, where they form intraganglionic laminar endings. Electrophysiological analysis revealed that they are low-threshold mechanoreceptors but possess different adaptation properties. Lastly, genetic ablation of Prox2 and Runx3 neurons demonstrated their essential roles for esophageal peristalsis in freely behaving mice. Our work defines the identity and function of the vagal neurons that provide mechanosensory feedback from the esophagus to the brain and could lead to better understanding and treatment of esophageal motility disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; other |
| اللغة: | English |
| Relation: | https://edoc.mdc-berlin.de/id/eprint/23368/1/23368oa.pdf; https://edoc.mdc-berlin.de/id/eprint/23368/3/23368suppl.zip; Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C. Neuron 111 (14): 2184-2200.e7. 19 July 2023; PMID:37192624 |
| الاتاحة: | https://edoc.mdc-berlin.de/id/eprint/23368/ https://edoc.mdc-berlin.de/23368/ https://edoc.mdc-berlin.de/id/eprint/23368/1/23368oa.pdf https://edoc.mdc-berlin.de/id/eprint/23368/3/23368suppl.zip |
| Rights: | cc_by_nc_nd_4 |
| رقم الانضمام: | edsbas.5693DD05 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |