Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure

التفاصيل البيبلوغرافية
العنوان:	Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure
المؤلفون:	Yuan, Yexian, Hu, Ruoci, Park, Jooman, Xiong, Shaolei, Wang, Zilai, Qian, Yanyu, Shi, Zuoxiao, Wu, Ruifan, Han, Zhenbo, Ong, Sang-Ging, Lin, Shuhao, Varady, Krista A., Xu, Pingwen, Berry, Daniel C., Shu, Gang, Jiang, Yuwei
المصدر:	Science Advances ; volume 10, issue 26 ; ISSN 2375-2548
بيانات النشر:	American Association for the Advancement of Science (AAAS)
سنة النشر:	2024
الوصف:	There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT. CCL22 injection into iWAT effectively promotes iWAT beiging, while blocking CCL22 with antibodies can prevent it. Mechanistically, the CCL22 receptor, C-C motif chemokine receptor 4 (CCR4), within eosinophils and its downstream focal adhesion kinase/p65/interleukin-4 signaling are essential for CCL22-mediated beige adipocyte formation. Moreover, CCL22 levels are inversely correlated with body weight and fat mass in mice and humans. Acute elevation of CCL22 levels effectively prevents diet-induced body weight and fat gain by enhancing adipose beiging. Together, our data identify the CCL22-CCR4 axis as an essential mediator for LN-controlled adaptive thermogenesis and highlight its potential to combat obesity and its associated complications.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1126/sciadv.adn5229
الاتاحة:	http://dx.doi.org/10.1126/sciadv.adn5229 https://www.science.org/doi/pdf/10.1126/sciadv.adn5229
رقم الانضمام:	edsbas.5685CB67
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1126/sciadv.adn5229