Academic Journal
Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome
| العنوان: | Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome |
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| المؤلفون: | Dechartres, Julie, Pawluski, Jodi L, Gueguen, Marie-Madeleine, Jablaoui, Amin, Maguin, Emmanuelle, Rhimi, Moez, Charlier, Thierry D |
| المساهمون: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique EHESP (EHESP), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, University of Rennes 1 (Bourse fléchée UR1), University of Rennes 1 (Défis Emergents 2018), La Région Bretagne (SAD), Rennes Métropole |
| المصدر: | ISSN: 0953-8194. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | cingulate gyrus, neurogenesis, gut microbiota, hippocampus, neuroplasticity, [SDV]Life Sciences [q-bio], [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; Glyphosate is found in a large array of non‐selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. Recent work in rodent models suggests that glyphosate‐based herbicides during development can affect neuronal communication and result in altered behaviours, albeit through undefined mechanisms of action. To our knowledge, no study has investigated the effects glyphosate or its formulation in herbicide on maternal behaviour and physiology. In the present study, relatively low doses of glyphosate (5 mg kg‐1 d‐1), Roundup® (5 mg kg‐1 d‐1 glyphosate equivalent), or vehicle were administered by ingestion to Sprague‐Dawley rats from gestational day (GD) 10 to postpartum day (PD)22. The treatments significantly altered licking behaviour toward pups between PD2 and PD6. We also show in the dams at PD22 that Roundup exposure affected the maturation of doublecortin‐immunoreactive new neurones in the dorsal dentate gyrus of the hippocampus of the mother. In addition, the expression of synaptophysin was up‐regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down‐regulated in the cingulate gyrus. Although a direct effect of glyphosate alone or its formulation on the central nervous system is currently not clear, we show that gut microbiota is significantly altered by the exposure to the pesticides, with significant alteration of the phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence that glyphosate alone or in formulation (Roundup) differentially affects maternal behaviour and modulates neuroplasticity and gut microbiota in the mother. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31066122; hal-02153623; https://univ-rennes.hal.science/hal-02153623; https://univ-rennes.hal.science/hal-02153623/document; https://univ-rennes.hal.science/hal-02153623/file/Dechartres%20et%20al-2019-Glyphosate%20and%20Glyphosate-based%20herbicide%20exposure%20during%20the%20peripartum%20period.pdf; PUBMED: 31066122 |
| DOI: | 10.1111/jne.12731 |
| الاتاحة: | https://univ-rennes.hal.science/hal-02153623 https://univ-rennes.hal.science/hal-02153623/document https://univ-rennes.hal.science/hal-02153623/file/Dechartres%20et%20al-2019-Glyphosate%20and%20Glyphosate-based%20herbicide%20exposure%20during%20the%20peripartum%20period.pdf https://doi.org/10.1111/jne.12731 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.56574170 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jne.12731 |
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