Academic Journal
Pigment epithelium-derived factor in ulcerative colitis:Possible relationship with disease activity
| العنوان: | Pigment epithelium-derived factor in ulcerative colitis:Possible relationship with disease activity |
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| المؤلفون: | Wiercinska-Drapalo, Alicja, Jaroszewicz, Jerzy, Parfieniuk, Anna, Lapinski, Tadeusz Wojciech, Rogalska, Magdalena, Prokopowicz, Danuta |
| المصدر: | Wiercinska-Drapalo , A , Jaroszewicz , J , Parfieniuk , A , Lapinski , T W , Rogalska , M & Prokopowicz , D 2007 , ' Pigment epithelium-derived factor in ulcerative colitis : Possible relationship with disease activity ' , Regulatory Peptides , vol. 140 , no. 1-2 , pp. 1-4 . https://doi.org/10.1016/j.regpep.2006.11.006 |
| سنة النشر: | 2007 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Angiogenesis, Pigment epithelium-derived factor, Ulcerative colitis, Vascular endothelial growth factor |
| الوصف: | Objectives: Pigment epithelium-derived factor (PEDF) is an endogenous most potential angiogenic inhibitor and increased expression of PEDF in intestinal mucosa specimens was shown in the course of ulcerative colitis (UC). The aim of the present study was to evaluate serum concentration of pigment epithelium-derived growth factor, a potent anti-angiogenic factor and its possible association with vascular endothelial growth factor (VEGF) levels and disease activity. Methods: Concentrations of PEDF and VEGF were measured in sera of 33 patients (13 females and 20 males) with active UC. Results: There was significant increase of serum PEDF (32.3 ± 2.9 vs. 20.6 ± 4.7 ng/mL, P < 0.05) as well as VEGF (326.4 ± 58.1 vs. 110.9 ± 15.7 pg/mL, P < 0.05) in UC patients compared to healthy controls. Serum PEDF showed strong, positive correlation with endoscopic score (r = 0.622, P < 0.001), while such association was absent in respect to VEGF (r = 0.05, P = 0.77). In contrast serum VEGF decreased in severe UC comparing to patients with a mild course of disease, however the difference was not significant (274.9 ± 64.9 vs. 360.4 ± 103.4 pg/mL, P = 0.53). Conclusions: Increase in serum PEDF during UC, especially in severe forms of disease suggests its involvement in UC pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.regpep.2006.11.006 |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/pigment-epitheliumderived-factor-in-ulcerative-colitis(059b4f3a-b860-4514-aecf-2b1b5dead6da).html https://doi.org/10.1016/j.regpep.2006.11.006 http://www.scopus.com/inward/record.url?scp=33847059656&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.564A9894 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.regpep.2006.11.006 |
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