Academic Journal
Modulatory effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity following cervical spinal cord contusion in the rat
| العنوان: | Modulatory effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity following cervical spinal cord contusion in the rat |
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| المؤلفون: | Lee, Kun Ze, Vinit, Stéphane |
| المساهمون: | Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM), National Science and Technology Council, Ministry of Science and Technology, Taiwan |
| المصدر: | ISSN: 1529-9430 ; Spine Journal ; https://hal.science/hal-04728550 ; Spine Journal, 2024, 24 (2), pp.352-372. ⟨10.1016/j.spinee.2023.09.013⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cervical spinal cord injury, Diaphragm, Intermittent theta burst stimulation, Magnetic stimulation, Spinal neuroplasticity, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background CONTEXT: Magnetic stimulation can noninvasively modulate the neuronal excitability through different stimulatory patterns. Purpose: The present study hypothesized that trans-spinal magnetic stimulation with intermittent theta burst stimulatory pattern can modulate respiratory motor outputs in a pre-clinical rat model of cervical spinal cord injury. Study design: In vivo animal study. Methods: The effect of trans-spinal magnetic intermittent theta burst stimulation on diaphragmatic activity was assessed in adult rats with unilateral cervical spinal cord contusion at 2 weeks postinjury. Results: The results demonstrated that unilateral cervical spinal cord contusion significantly attenuated the inspiratory activity and motor evoked potential of the diaphragm. Trans-spinal magnetic intermittent theta burst stimulation significantly increased the inspiratory activity of the diaphragm in cervical spinal cord contused rats. Inspiratory bursting was also recruited by trans-spinal magnetic intermittent theta burst stimulation in the rats without diaphragmatic activity after cervical spinal cord injury. In addition, trans-spinal magnetic intermittent theta burst stimulation is associated with increases in oxygen consumption and carbon dioxide production. Conclusions: These results suggest that trans-spinal magnetic intermittent theta burst stimulation can induce respiratory neuroplasticity. Clinical significance: We propose that trans-spinal theta burst magnetic stimulation may be considered a potential rehabilitative strategy for improving the respiratory activity after cervical spinal cord injury. This will require future clinical study. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37774983; PUBMED: 37774983 |
| DOI: | 10.1016/j.spinee.2023.09.013 |
| الاتاحة: | https://hal.science/hal-04728550 https://doi.org/10.1016/j.spinee.2023.09.013 |
| Rights: | http://hal.archives-ouvertes.fr/licences/copyright/ |
| رقم الانضمام: | edsbas.562EAE5C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.spinee.2023.09.013 |
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