التفاصيل البيبلوغرافية
| العنوان: |
Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex |
| المؤلفون: |
EPISTOP consortium |
| المساهمون: |
Opleiding Neurologie, Brain, Onderzoek NCH, MS Radiologie, Circulatory Health, Neurologen |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Brain/diagnostic imaging, Child, Preschool, Cognition Disorders/epidemiology, Cohort Studies, Epilepsy/epidemiology, Female, Follow-Up Studies, Humans, Infant, Language Development Disorders/epidemiology, Magnetic Resonance Imaging, Neurodevelopmental Disorders/epidemiology, Pregnancy, Retrospective Studies, TSC, Tuberous Sclerosis/epidemiology, development, epilepsy, fetal, imaging, Pediatrics, Perinatology, and Child Health, Research Support, Non-U.S. Gov't, Multicenter Study, Journal Article |
| الوصف: |
Objective: To correlate fetal brain magnetic resonance imaging (MRI) findings with epilepsy characteristics and neurodevelopment at 2 years of age in children with tuberous sclerosis complex (TSC) to improve prenatal counseling. Study design: This retrospective cohort study was performed in a collaboration between centers of the EPISTOP consortium. We included children with definite TSC, fetal MRIs, and available follow-up data at 2 years of age. A pediatric neuroradiologist masked to the patient's clinical characteristics evaluated all fetal MRIs. MRIs were categorized for each of the 10 brain lobes as score 0: no (sub)cortical lesions or doubt; score 1: a single small lesion; score 2: more than one small lesion or at least one large lesion (>5 mm). Neurologic manifestations were correlated to lesion sum scores. Results: Forty-one children were included. Median gestational age at MRI was 33.3 weeks; (sub)cortical lesions were detected in 97.6%. Mean lesion sum score was 4.5. At 2 years, 58.5% of patients had epilepsy and 22% had drug-resistant epilepsy. Cognitive, language, and motor development were delayed in 38%, 81%, and 50% of patients, respectively. Autism spectrum disorder (ASD) was diagnosed in 20.5%. Fetal MRI lesion sum scores were significantly associated with cognitive and motor development, and with ASD diagnosis, but not with epilepsy characteristics. Conclusions: Fetal cerebral lesion scores correlate with neurodevelopment and ASD at 2 years in children with TSC. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0022-3476 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/444541 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/444541 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.560B6A8C |
| قاعدة البيانات: |
BASE |