Academic Journal
Interleukin 10 (IL10) promoter region polymorphism is associated with IL10 serum concentrations and processing speed in healthy community-dwelling older adults
| العنوان: | Interleukin 10 (IL10) promoter region polymorphism is associated with IL10 serum concentrations and processing speed in healthy community-dwelling older adults |
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| المؤلفون: | Keegan, Andrew P., Savage, Karen, Bousman, Chad A., Nolidin, Karen, Cribb, Lachlan, Pipingas, Andrew, Stough, Con |
| المساهمون: | Swinburne University of Technology |
| المصدر: | Behavioural Brain Research, Vol. 458 (Feb 2024), 114756 |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2024 |
| المجموعة: | Swinburne University of Technology: Swinburne Research Bank |
| الوصف: | Inflammation is repressed by interleukin 10 (IL10), a potent anti-inflammatory cytokine, and unchecked inflammation can have detrimental effects on cognition. In healthy older adults enrolled in the Australian Research Council Longevity Intervention (ARCLI) cohort we explored whether a known functional single nucleotide polymorphism (SNP) in the promoter region of IL10, −1082 G/A (rs1800896), was associated with reaction times on computerized cognitive testing that included elements of processing speed (i.e., reaction time). Participants were aged 60–75 years (240 females, 158 males), free of dementia and psychiatric disorders, and provide a blood sample. Processing speed was measured using the Swinburne University Computerized Cognitive Assessment Battery (SUCCAB), which includes measures of reaction time (in milliseconds, ms) on six tasks. Blood-derived DNA was genotyped for the IL10 rs1800896 SNP and presence of the APOE E4 allele. General linear models for each SUCCAB subtest were fitted, with age, sex, education (years), APOE E4 carrier status, and IL10 genotype as independent variables. Carriers of the IL10 AA genotype had significantly slower reaction times on multiple tests compared to carriers of the minor allele (AG, GG) and lower IL10 serum levels. Although IL10 SNPs have not been detected in Alzheimer's disease genome-wide associated studies, these results support further exploration of IL10 mechanisms as a possible resilience factor. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://purl.org/au-research/grants/arc/DP1093825; http://hdl.handle.net/1959.3/476117; https://doi.org/10.1016/j.bbr.2023.114756 |
| DOI: | 10.1016/j.bbr.2023.114756 |
| الاتاحة: | http://hdl.handle.net/1959.3/476117 https://doi.org/10.1016/j.bbr.2023.114756 |
| Rights: | Copyright © 2024 |
| رقم الانضمام: | edsbas.5600756E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bbr.2023.114756 |
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