smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye

التفاصيل البيبلوغرافية
العنوان:	smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye
المؤلفون:	Vrailas, Alysia D., Marenda, Daniel R., Cook, Summer E., Powers, Maureen A., Lorenzen, James A., Perkins, Lizabeth A., Moses, Kevin
بيانات النشر:	Company of Biologists
سنة النشر:	2006
المجموعة:	HighWire Press (Stanford University)
مصطلحات موضوعية:	RESEARCH ARTICLES
الوصف:	The Drosophila Mitogen Activated Protein Kinase (MAPK) Rolled is a key regulator of developmental signaling, relaying information from the cytoplasm into the nucleus. Cytoplasmic MEK phosphorylates MAPK (pMAPK), which then dimerizes and translocates to the nucleus where it regulates transcription factors. In cell culture, MAPK nuclear translocation directly follows phosphorylation, but in developing tissues pMAPK can be held in the cytoplasm for extended periods (hours). Here, we show that Moleskin antigen ( Drosophila Importin 7/Msk), a MAPK transport factor, is sequestered apically at a time when lateral inhibition is required for patterning in the developing eye. We suggest that this apical restriction of Msk limits MAPK nuclear translocation and blocks Ras pathway nuclear signaling. Ectopic expression of Msk overcomes this block and disrupts patterning. Additionally, the MAPK cytoplasmic hold is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors.
نوع الوثيقة:	text
وصف الملف:	text/html
اللغة:	English
Relation:	http://dev.biologists.org/cgi/content/short/133/8/1485; http://dx.doi.org/10.1242/dev.02334
DOI:	10.1242/dev.02334
الاتاحة:	http://dev.biologists.org/cgi/content/short/133/8/1485 https://doi.org/10.1242/dev.02334
Rights:	Copyright (C) 2006, Company of Biologists
رقم الانضمام:	edsbas.55F32099
قاعدة البيانات:	BASE

View record in BASE

الوصف
DOI:	10.1242/dev.02334