Academic Journal
Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer
| العنوان: | Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer |
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| المؤلفون: | Op den Kamp, C.M.H., de Ruysscher, D.K.M., van den Heuvel, M., Elferink, M., Houben, R.M.A., Oberije, C.J.G., Bootsma, G.P., Geraedts, W.H., Pitz, C.C.M., Langen, R.C., Wouters, E.F.M., Schols, A.M.W.J., Dingemans, A.M.C. |
| المصدر: | Op den Kamp , C M H , de Ruysscher , D K M , van den Heuvel , M , Elferink , M , Houben , R M A , Oberije , C J G , Bootsma , G P , Geraedts , W H , Pitz , C C M , Langen , R C , Wouters , E F M , Schols , A M W J & Dingemans , A M C 2014 , ' Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer ' , Journal of cachexia, sarcopenia and muscle .... |
| سنة النشر: | 2014 |
| المجموعة: | Maastricht University Research Publications |
| الوصف: | BACKGROUND AND PURPOSE: Radiation-esophagitis and weight loss are observed toxicities in patients treated with concurrent chemo- (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The was to investigate whether weight loss already starts early after CT-RT and precedes radiation-esophagitis. MATERIALS AND METHODS: In a retrospective cohort, weight and esophagitis grade >/=2 were assessed first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on weight, esophagitis grade >/=2, nutritional intake and muscle strength obtained before, during and following CT-RT. RESULTS: In the cohort, early weight loss was observed in concurrently treated patients 0.002), independent of esophagitis >/= grade 2. Early weight loss was observed in the prospective cohort (p = 0.003) and was not accompanied decreases in nutritional intake. In addition lower limb muscle strength declined (p = 0.042). In the later weeks of treatment, further body occurred (p < 0.001) despite increased nutritional supplementation and weight was only partly recovered after 4 weeks post CT-RT (p = 0.003). CONCLUSIONS: Weight loss during concurrent CT-RT for NSCLC starts early to onset of esophagitis, requiring timely and intense nutritional |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s13539-013-0127-5 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/209975e9-f70a-4493-b625-73b73400e5cc https://doi.org/10.1007/s13539-013-0127-5 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.55E22D6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13539-013-0127-5 |
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