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Analysis of tubular proliferation and atrophy in neonatal mice following UUO.
| العنوان: | Analysis of tubular proliferation and atrophy in neonatal mice following UUO. |
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| المؤلفون: | Maja Wyczanska, Jana Rohling, Ursula Keller, Marcus R. Benz, Carsten Kirschning, Bärbel Lange-Sperandio |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Marine Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, urinary tract obstruction, toll like receptors, relative expression levels, inborn obstructive nephropathies, endogenous danger signals, congenital obstructive nephropathy, renal development leads, renal cells play, neonatal mouse model, >< sup ><, uuo induced neonatally, stage kidney disease, div >< p, nd , tlr2 mediates apoptosis, neonatal mice subjected, renal injury, tlr2 <, tubular apoptosis, interstitial apoptosis |
| الوصف: | Immunohistochemical staining of Ki67 (A and B) and proximal (prox) and distal (dist) atrophic tubules (D and E) in neonatal UUO WT (A and D) and Tlr2 -/- (B and E) mice at day 7. Quantification of Ki67-positive tubular cells in UUO-kidneys (C) shows a decrease following UUO without significant differences between WT and Tlr2 -/- . Quantitative analysis of tubular atrophy in UUO-kidneys on day 7 and day 14 (F) shows an increase of tubular atrophy in proximal and distal tubules following UUO, but no significant differences between WT and Tlr2 -/- mice in neither compartment. Results are indicated as x-fold increase above sham operated control in 20 hpfs; n = 8. Data are presented as mean +/- SEM. Bar = 100μm. Standalone * represents significant differences between Sham and UUO results. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Analysis_of_tubular_proliferation_and_atrophy_in_neonatal_mice_following_UUO_/24652603 |
| DOI: | 10.1371/journal.pone.0294142.g005 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0294142.g005 https://figshare.com/articles/figure/Analysis_of_tubular_proliferation_and_atrophy_in_neonatal_mice_following_UUO_/24652603 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.55BE0C1A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0294142.g005 |
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