Academic Journal
Comparative evaluation of methods for obtaining the stress-free geometry of keratoconus corneas with different levels of severity
| العنوان: | Comparative evaluation of methods for obtaining the stress-free geometry of keratoconus corneas with different levels of severity |
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| المؤلفون: | Gómez García, Carmelo, Piñero Llorens, David Pablo, Alió Sanz, Jorge Luciano, Cavas Martínez, Francisco |
| المساهمون: | Instituto de Salud Carlos III |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Politécnica de Cartagena: Repositorio Digital UPCT |
| مصطلحات موضوعية: | Corneal biomechanics, Finite elements, Patient-specific models, Corneal ectasia, Expresión Gráfica en Ingeniería, 2209 Óptica, 2410 Biología Humana, 3210 Medicina Preventiva |
| الوصف: | A biomechanical model that simulates the physiological pressure load on the cornea without considering the stresses in vivo will result in an overstress or underestimation of the stress field and incorrect deformation of the corneal structure. Therefore, it is essential to propose numerical models that consider the stress-free geometry of the cornea. In this study, the Displacement and Pre-stress methods were compared to obtain the stress-free geometry (S-FG) and the physiological estimated geometry (P-EG), based on the patient-specific geometric behavior and the computational time required to reach each geometry. The same shape and contour conditions were considered in the models obtained from both methods for each of the pathological scenarios analyzed. Both methods behaved differently to obtain the free geometry, and this difference increased with the severity grade of the disease. However, they behaved in a similar way to reach the physiological estimated geometry. The Displacement method required a lower computational cost to reach the free geometry, with both methods presenting a similar computational cost to obtain the physiological geometry. The stress-free geometries obtained by both methods allowed to characterize the existing biomechanical decompensation during the progression of the diseases. In conclusion, the calculation of the stress-free corneal geometry associated to the clinically measured intraocular pressure with the Displacement and Prestress Methods in keratoconus eyes allows the development of accurate and useable models in clinical practice in real time. This displacement method shows some benefits in terms of computational cost. ; This publication was carried out within the framework of the project “Desarrollo y validación de un nuevo concepto de caracterización biomecánica-morfofuncional de la córnea” reference number DTS21/00103. This project has been funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0010-4825 |
| Relation: | Biomecánica corneal paciente-específico: avances en las técnicas de caracterización, modelización y simulación; GÓMEZ GARCÍA, C. et al. Comparative evaluation of methods for obtaining the stress-free geometry of keratoconus corneas with different levels of severity. En: Computers in Biology and Medicine. 2024, 170: 107870. https://doi.org/10.1016/j.compbiomed.2023.107870; http://hdl.handle.net/10317/13845; https://www.sciencedirect.com/science/article/pii/S0010482523013355?via%3Dihub |
| DOI: | 10.1016/j.compbiomed.2023.107870 |
| الاتاحة: | http://hdl.handle.net/10317/13845 https://doi.org/10.1016/j.compbiomed.2023.107870 https://www.sciencedirect.com/science/article/pii/S0010482523013355?via%3Dihub |
| Rights: | Atribución-NoComercial-SinDerivadas 3.0 España ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| رقم الانضمام: | edsbas.55A46410 |
| قاعدة البيانات: | BASE |
| تدمد: | 00104825 |
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| DOI: | 10.1016/j.compbiomed.2023.107870 |