Academic Journal
Impact of TP53 Mutation Status in Elderly AML Patients When Adding All‐ Trans Retinoic Acid or Valproic Acid to Decitabine
| العنوان: | Impact of TP53 Mutation Status in Elderly AML Patients When Adding All‐ Trans Retinoic Acid or Valproic Acid to Decitabine |
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| المؤلفون: | Bresser, Helena, Schmoor, Claudia, Grishina, Olga, Pfeifer, Dietmar, Thomas, Johanna, Rehman, Usama‐Ur, Crysandt, Martina, Jost, Edgar, Thol, Felicitas, Heuser, Michael, Götze, Katharina S., Schlenk, Richard F., Salih, Helmut R., Schittenhelm, Marcus M., Heil, Gerhard, Schwaenen, Carsten, Müller‐Tidow, Carsten, Brugger, Wolfram, Kündgen, Andrea, de Wit, Maike, Giagounidis, Aristoteles, Scholl, Sebastian, Neubauer, Andreas, Krauter, Jürgen, Bug, Gesine, May, Annette M., Wäsch, Ralph, Duyster, Justus, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut, Hackanson, Björn, Becker, Heiko, Lübbert, Michael |
| المصدر: | European Journal of Haematology ; volume 114, issue 2, page 231-237 ; ISSN 0902-4441 1600-0609 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In a randomized phase II trial (AMLSG 14‐09, NCT00867672) of elderly, newly diagnosed AML patients, ATRA combined with decitabine (DEC) significantly improved the overall response rate (ORR) and survival also in patients with adverse‐risk genetics, without adding toxicity. We performed a post hoc analysis to determine the predictive impact of TP53 status. Despite a nominally higher ORR, the clinically meaningful survival benefit when adding ATRA to DEC was diminished, but not completely negated, in TP53 ‐mutated patients. Indeed, 2 out of 14 TP53 ‐mutated patients (14%) randomized to a DEC + ATRA‐containing regimen lived for > 36 months. Further studies of ATRA combined with hypomethylating agents appear warranted in non‐M3 AML patients ineligible for HMA/venetoclax therapy. Trial Registration: ClinicalTrials.gov identifier: NCT00867672 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/ejh.14304 |
| الاتاحة: | https://doi.org/10.1111/ejh.14304 https://onlinelibrary.wiley.com/doi/pdf/10.1111/ejh.14304 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.5561277D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/ejh.14304 |
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