التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis? |
| المؤلفون: |
Ciccarelli, Giovanni, Conte, Stefano, Cimmino, Giovanni, Maiorano, Patrizia, Morrione, Andrea, Giordano, Antonio, Ciccarelli|0000-0001-6919-899X, Morrione|0000-0002-2319-7884, Giordano|0000-0002-5959-016X |
| المساهمون: |
Sbarro Health Research Organization (SHRO) (Temple University) |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Aging, Atherosclerosis, Cardiovascular disease, Coronary, Endothelium, Mitochondrial disorders, Therapies to counteract mitochondrial dysfunction |
| الوصف: |
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes. Improvements in therapy have drastically reduced the prognosis of cardiovascular disease. Nevertheless, a significant residual risk is still relevant, and is related to unmet therapeutic targets. Endothelial dysfunction and lipid infiltration are the primary causes of atherosclerotic plaque progression. In this contest, mitochondrial dysfunction can affect arterial wall cells, in particular macrophages, smooth muscle cells, lymphocytes, and endothelial cells, causing an increase in reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation, and intracellular lipid deposition. The detection and characterization of mitochondrial DNA (mtDNA) is crucial for assessing mitochondrial defects and should be considered the goal for new future therapeutic interventions. In this review, we will focus on a new idea, based on the analysis of data from many research groups, namely the link between mitochondrial impairment and endothelial dysfunction and, in particular, its effect on atherosclerosis and aging. Therefore, we discuss known and novel mitochondria-targeting therapies in the contest of atherosclerosis. ; Temple University. College of Science and Technology ; Biology |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
12 pages |
| اللغة: |
English |
| Relation: |
MDPI; https://doi.org/10.3390/ijms24021086; International Journal of Molecular Sciences, Vol. 24, Iss. 2; Faculty/ Researcher Works; Ciccarelli, G.; Conte, S.; Cimmino, G.; Maiorano, P.; Morrione, A.; Giordano, A. Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis? Int. J. Mol. Sci. 2023, 24, 1086. https://doi.org/10.3390/ijms24021086; http://hdl.handle.net/20.500.12613/10826 |
| الاتاحة: |
https://hdl.handle.net/20.500.12613/10826 |
| Rights: |
Attribution CC BY ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.555DA62E |
| قاعدة البيانات: |
BASE |