Academic Journal
Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty
| العنوان: | Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty |
|---|---|
| المؤلفون: | Di Marino, Sara, Viceconte, Nicola, Lembo, Angelo, Summa, Vincenzo, Tanzilli, Gaetano, Raparelli, Valeria, Truscelli, Giovanni, Mangieri, Enrico, Gaudio, Carlo, Cicero, Daniel Oscar |
| المساهمون: | Di Marino, Sara, Viceconte, Nicola, Lembo, Angelo, Summa, Vincenzo, Tanzilli, Gaetano, Raparelli, Valeria, Truscelli, Giovanni, Mangieri, Enrico, Gaudio, Carlo, Cicero, Daniel Oscar |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2018 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | biostatistic, cardiac catheterization and angiography, chronic coronary disease, coronary artery disease, percutaneous coronary intervention |
| الوصف: | Objective: Balloon-induced transient coronary ischaemia represents a model of myocardial ischaemia and reperfusion. We are interested in the very early systemic metabolic response to this event. Methods: Blood samples of patients with stable angina (SA) were collected before and after coronary angioplasty. Serum metabolic profiles were obtained using nuclear magnetic resonance spectroscopy. Univariate and multivariate analyses were used to investigate changes in metabolite concentrations. Results: Thirty-four consecutive patients with SA, undergoing elective coronary angioplasty at Policlinico Umberto I of Rome, were included in this study. Changes in metabolites concentration induced by balloon occlusion in venous and arterial sera were detected. In both serum types, a significant increase in ketone bodies, 2-hydroxybutyrate, glutamine and O-acetylcarnitine concentration is observed, while alanine, lactate, phenylalanine and tyrosine decreased after intervention. Most significant metabolic changes were detected in arterial serum. Conclusions: Our study points out two main global metabolic changes in peripheral blood after balloon-induced coronary ischaemia: ketone bodies increase and lactate decrease. Both could be related to compensation mechanisms finalised to fulfil heart's needs after short period of myocardial ischaemia and probably after reperfusion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29632675; info:eu-repo/semantics/altIdentifier/wos/WOS:000427076500016; volume:5; issue:1; numberofpages:8; journal:OPEN HEART; http://hdl.handle.net/11573/1087840; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85059921823 |
| DOI: | 10.1136/openhrt-2017-000709 |
| الاتاحة: | http://hdl.handle.net/11573/1087840 https://doi.org/10.1136/openhrt-2017-000709 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.55424E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/openhrt-2017-000709 |
|---|