Academic Journal
Identification of a Role for Nucleolin in Rabies Virus Infection
| العنوان: | Identification of a Role for Nucleolin in Rabies Virus Infection |
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| المؤلفون: | Oksayan, S, Nikolic, J, David, CT, Blondel, D, Jans, DA, Moseley, GW |
| المساهمون: | López, S |
| بيانات النشر: | AMER SOC MICROBIOLOGY |
| سنة النشر: | 2015 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Full text Embargoed until: 2015-08-31 ; Rabies virus replicates in the cytoplasm of host cells, but rabies virus phosphoprotein (P-protein) undergoes active nucleocytoplasmic trafficking. Here we show that the largely nuclear P-protein isoform P3 can localize to nucleoli and forms specific interactions with nucleolin. Importantly, depletion of nucleolin expression inhibits viral protein expression and infectious virus production by infected cells. This provides the first evidence that lyssaviruses interact with nucleolin and that nucleolin is important to lyssavirus infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-538X 1098-5514 |
| Relation: | NHMRC/1003244; pii: JVI.03320-14; Oksayan, S., Nikolic, J., David, C. T., Blondel, D., Jans, D. A. & Moseley, G. W. (2015). Identification of a Role for Nucleolin in Rabies Virus Infection. JOURNAL OF VIROLOGY, 89 (3), pp.1939-1943. https://doi.org/10.1128/JVI.03320-14.; http://hdl.handle.net/11343/44239 |
| الاتاحة: | http://hdl.handle.net/11343/44239 |
| رقم الانضمام: | edsbas.553C837F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0022538X 10985514 |
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