Academic Journal
Original Contribution Early Blood Gas Abnormalities and the Preterm Brain
| العنوان: | Original Contribution Early Blood Gas Abnormalities and the Preterm Brain |
|---|---|
| المؤلفون: | Alan Leviton* Elizabeth Allred, Deborah Hirtz, Michael D. Schreiber, Nigel Paneth, Elgan Study Investigators |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984251/pdf/kwq222.pdf?origin%3Dpublication_detail. |
| سنة النشر: | 2010 |
| المجموعة: | CiteSeerX |
| الوصف: | The authors explored associations between blood gas abnormalities in more than 1,000 preterm infants during the first postnatal days and indicators of neonatal brain damage. During 2002–2004, women delivering infants before 28 weeks ’ gestation at one of 14 participating institutions in 5 US states were asked to enroll in the study. The authors compared infants with blood gas values in the highest or lowest quintile for gestational age and postnatal day (extreme value) on at least 1 of the first 3 postnatal days with the remainder of the subjects, with separate analyses for blood gas abnormalities on multiple days and for partial pressure of oxygen in the alveolar gas of <35. Outcomes analyzed were ventriculomegaly and an echolucent lesion on an ultrasound scan in the neonatal intensive care unit, and cerebral palsy, microcephaly, and a low score on a Bayley Scale of Infant Development at 24 months. Every blood gas derangement (hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidosis) was associated with multiple indicators of brain damage. However, for some, the associations were seen with only 1 day of exposure; others were evident with 2 or more days ’ exposure. Findings suggest that individual blood gas derangements do not increase brain damage risk. Rather, the multiple derangements asso-ciated with indicators of brain damage might be indicators of immaturity/vulnerability and illness severity. blood gas analysis; brain; infant, newborn; leukomalacia, periventricular; premature birth Abbreviations: ELGAN, extremely low gestational age newborn; MDI, mental development index; PaO2, partial pressure of oxygen |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.662.9919; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984251/pdf/kwq222.pdf?origin%3Dpublication_detail |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.662.9919 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984251/pdf/kwq222.pdf?origin%3Dpublication_detail |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.552D88B0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |