Academic Journal
Additional file 1 of Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants
| العنوان: | Additional file 1 of Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants |
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| المؤلفون: | Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Pharmacology, Science Policy, Biological Sciences not elsewhere classified, APOE-Christchurch variant, Alzheimer’s disease, Rare variants |
| الوصف: | Additional file 1: Table S1. Characteristics of APOE Christchurch variant carriers and matched noncarriers in UKB European samples. Table S2. List of self-reported cardiovascular conditions included for analyses. Table S3. List of self-reported and primary care prescription medications used for analyses. Table S4. List of quantitative traits assessed for carriers and noncarriers. Table S5. APOE genotype of APOECh carriers and matched noncarriers. Table S6. Screening APOECh carriers for APOE protective variants and mutations reported for neurodegenerative disorders with a Mendelian inheritance. Table S7. Empirical p-values of binary traits. Table S8. Kolmogorov-Smirnov test of quantitative traits and PRS among all 36 carriers and matching controls. Table S9. Mendelian randomization of statin-adjusted apoB and AD. Table S10. Availability and overlap of APOECh carriers with brain imaging, metabolomics, and proteomics data. Table S11. Summary of phenotypic data availability for carriers and noncarriers. Table S12. Linear and logistic regression of HDL, LDL, CVD, and AD with PRS as a covariate between APOECh carriers and noncarriers. Figure S1. Selection of APOE Christchurch carriers and matched controls from the UK Biobank. Figure S2. Cumulative distributions of physical measures and Kolmogorov-Smirnov test results. Figure S3. Cumulative distributions of urine biomarkers and Kolmogorov-Smirnov test results. Figure S4. Cumulative distributions of blood biomarkers and Kolmogorov-Smirnov test results. Figure S5. Cumulative distributions of hematological traits and Kolmogorov-Smirnov test results. Figure S6. Cumulative distributions of lipid biomarkers and Kolmogorov-Smirnov test results. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Additional_file_1_of_Characterization_of_APOE_Christchurch_carriers_in_455_306_UK_Biobank_participants/24655908 |
| DOI: | 10.6084/m9.figshare.24655908.v1 |
| الاتاحة: | https://doi.org/10.6084/m9.figshare.24655908.v1 https://figshare.com/articles/journal_contribution/Additional_file_1_of_Characterization_of_APOE_Christchurch_carriers_in_455_306_UK_Biobank_participants/24655908 |
| Rights: | CC BY + CC0 |
| رقم الانضمام: | edsbas.54E7AA16 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.24655908.v1 |
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