Academic Journal
Control of Multi-Resistant Bacteria and Ventilator-Associated Pneumonia: Is It Possible with Changes in Antibiotics?
| العنوان: | Control of Multi-Resistant Bacteria and Ventilator-Associated Pneumonia: Is It Possible with Changes in Antibiotics? |
|---|---|
| المؤلفون: | Elisa M Jukemura, Marcelo N Burattini, Carlos A P Pereira, Alfésio L F Braga, Eduardo A S Medeiros |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.sociedad-iih.cl/doc_biblioteca/consejos_guias/34-ControldebacteriasmultiresistentesyNAVM.pdf. |
| سنة النشر: | 2007 |
| المجموعة: | CiteSeerX |
| الوصف: | Potent antimicrobial agents have been developed as a response to the development of antibiotic-resistant bacteria, which especially affect patients with prolonged hospitalization in Intensive Care Units (ICU) and who had been previously treated with antimicrobials, especially third-generation cephalosporins.This study was to determine how changes in the empirical treatment of infections in ICU patients affect the incidence of Gram-negative bacteria species and their susceptibility to antimicrobials, and examine the impact of these changes on nosocomial infections. A prospective interventional study was performed in a university hospital during two periods: 1) First period (September 1999 to February 2000); and 2) Second period (August 2000 to December 2000); empirical treatment was changed from ceftriaxone and/or ceftazidime in the first period to piperacillin/tazobactam in the second. ICU epidemiological and infection control rates, as well as bacterial isolates from upper airways were analyzed. Ceftazidime consumption dropped from 34.83 to 0.85 DDD/1000 patients per day (p=0.004). Piperacillin/tazobactam was originally not available; its consumption reached 157.07 DDD/1000 patients per day in the second period (p=0.0002). Eighty-seven patients and 66 patients were evaluated for upper airway colonization in the first and second periods, respectively. There was a significant decrease in the incidence of K. pneumoniae (p=0.004) and P. mirabilis (p=0.036), restoration of K. pneumoniae susceptibility to cephalosporins (p<0.0001) and reduction of ventilator-associated pneumonia rates (p<0.0001). However, there was an increase in P. aeruginosa incidence (p=0.005) and increases in ceftazidime (p=0.003) and meropenem (p<0.0001) susceptibilities. Changing antimicrobial selective pressure on multi-resistant Gram-negative bacteria helps control ventilator-associated pneumonia and decreases antimicrobial resistance. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.5147; http://www.sociedad-iih.cl/doc_biblioteca/consejos_guias/34-ControldebacteriasmultiresistentesyNAVM.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.5147 http://www.sociedad-iih.cl/doc_biblioteca/consejos_guias/34-ControldebacteriasmultiresistentesyNAVM.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.54D21564 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |