Academic Journal
Pro-aromatic Natural Terpenes as Unusual “Slingshot” Antioxidants with Promising Ferroptosis Inhibition Activity
| العنوان: | Pro-aromatic Natural Terpenes as Unusual “Slingshot” Antioxidants with Promising Ferroptosis Inhibition Activity |
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| المؤلفون: | Jin Z., Mollica F., Huang Y., Guernelli S., Baschieri A., Diquigiovanni C., Rizzardi N., Valenti F., Pincigher L., Bergamini C., Amorati R. |
| المساهمون: | Jin, Z., Mollica, F., Huang, Y., Guernelli, S., Baschieri, A., Diquigiovanni, C., Rizzardi, N., Valenti, F., Pincigher, L., Bergamini, C., Amorati, R. |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Antioxidant, Essential oil, Ferroptosi, Lipid peroxidation, Superoxide |
| الوصف: | Ferroptosis is a cell death mechanism based on extensive cellular membrane peroxidation, implicated in neurodegenerative and other diseases. The essential oil component gamma-terpinene, a natural monoterpene with a unique highly oxidizable pro-aromatic 1,4-cyclohexadiene skeleton, inhibits peroxidation of polyunsaturated lipid in model heterogeneous systems (micelles and liposomes). Upon H-atom abstraction, an unstable gamma-terpinene-derived peroxyl radical is formed, that aromatizes to p-cymene generating HOO & sdot; radicals. As HOO & sdot; are small and hydrophilic radicals, they quickly diffuse outside the lipid core, blocking the radical chain propagation of polyunsaturated lipids. This unprecedented antioxidant "slingshot" mechanism explains why gamma-terpinene shows a protective activity against ferroptosis, being effective at submicromolar concentrations in human neuroblastoma (SH-SY5Y) cells. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39392313; info:eu-repo/semantics/altIdentifier/wos/WOS:001354129400001; volume:e202403320; firstpage:1; lastpage:6; numberofpages:6; journal:CHEMISTRY; https://hdl.handle.net/11585/997983 |
| DOI: | 10.1002/chem.202403320 |
| الاتاحة: | https://hdl.handle.net/11585/997983 https://doi.org/10.1002/chem.202403320 https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202403320 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.54CE4791 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/chem.202403320 |
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