Academic Journal
Synthesis of coumarin derivatives and their cytoprotective effects on t-BHP-induced oxidative damage in HepG2 cells
| العنوان: | Synthesis of coumarin derivatives and their cytoprotective effects on t-BHP-induced oxidative damage in HepG2 cells |
|---|---|
| المؤلفون: | Ando, Tomomi, Nagumo, Mina, Ninomiya, Masayuki, Tanaka, Kaori, Linhardt, Robert J., Koketsu, Mamoru |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Biology, Chemistry and chemical biology, Chemical and biological engineering, Biomedical engineering |
| الوصف: | Bioorganic & Medicinal Chemistry Letters, 28, 2422-2425 ; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. ; Coumarins are ubiquitous in higher plants and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of coumarin derivatives on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in human hepatoma HepG2 cells. A series of coumarin derivatives were prepared and assessed for their cytoprotective effects. Among these, a caffeoyl acid-conjugated dihydropyranocoumarin derivative, caffeoyllomatin, efficiently protected against cell damage elicited by t-BHP. Our findings suggest that caffeoyllomatin appears to be a potent cytoprotective agent. ; https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.bmcl.2018.06.018 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 14643405 0960894X |
| Relation: | The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS); The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Bioorganic and Medicinal Chemistry Letters; https://harc.rpi.edu/; https://doi.org/10.1016/j.bmcl.2018.06.018; https://hdl.handle.net/20.500.13015/5587 |
| DOI: | 10.1016/j.bmcl.2018.06.018 |
| الاتاحة: | https://hdl.handle.net/20.500.13015/5587 https://doi.org/10.1016/j.bmcl.2018.06.018 |
| Rights: | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ |
| رقم الانضمام: | edsbas.54BA28C |
| قاعدة البيانات: | BASE |
| تدمد: | 14643405 0960894X |
|---|---|
| DOI: | 10.1016/j.bmcl.2018.06.018 |