Academic Journal
IGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre
| العنوان: | IGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre |
|---|---|
| المؤلفون: | Edner, Natalie M, Houghton, Luke P, Ntavli, Elisavet, Rees-Spear, Chloe, Petersone, Lina, Wang, Chunjing, Fabri, Astrid, Elfaki, Yassin, Gonzalez, Andrea Rueda, Brown, Rachel, Kisand, Kai, Peterson, Paert, Mccoy, Laura E, Walker, Lucy SK |
| المصدر: | Frontiers in Immunology , 15 , Article 1395684. (2024) |
| بيانات النشر: | FRONTIERS MEDIA SA |
| سنة النشر: | 2024 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | follicular helper T cells, antibody response, TIGIT, B cell help, COVID-19 |
| الوصف: | Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have explored how cTfh phenotype relates to the titre and quality of antibody responses. Severe disease was associated with higher titres of neutralising S1 IgG and evidence of increased T cell activation. ICOS, CD38 and HLA-DR expressing cTfh correlated with serum S1 IgG titres and neutralising strength, and interestingly expression of TIGIT by cTfh showed a negative correlation. TIGIT+cTfh expressed increased IFNγ and decreased IL-17 compared to their TIGIT-cTfh counterparts, and showed reduced capacity to help B cells in vitro. Additionally, TIGIT+cTfh expressed lower levels of CD40L than TIGIT-cTfh, providing a potential explanation for their poor B-helper function. These data identify phenotypic changes in polyclonal cTfh that correlate with specific antibody responses and reveal TIGIT as a marker of cTfh with altered function. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10203439/1/Edner%20et%20al%20for%20upload.pdf; https://discovery.ucl.ac.uk/id/eprint/10203439/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10203439/1/Edner%20et%20al%20for%20upload.pdf https://discovery.ucl.ac.uk/id/eprint/10203439/ |
| Rights: | open |
| رقم الانضمام: | edsbas.5458FAF5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |