Academic Journal
Inkjet printing of paraffin on paper allows low-cost point-of-care diagnostics for pathogenic fungi
| العنوان: | Inkjet printing of paraffin on paper allows low-cost point-of-care diagnostics for pathogenic fungi |
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| المؤلفون: | Prabhu, Anusha, Giri Nandagopal, M. S., Peralam Yegneswaran, Prakash, Singhal, Hardik Ramesh, Mani, Naresh Kumar |
| المساهمون: | Vision Group on Science and Technology, Government of Karnataka, Manipal McGill Centre for Infectious Diseases, Indian Council of Medical Research |
| المصدر: | Cellulose ; volume 27, issue 13, page 7691-7701 ; ISSN 0969-0239 1572-882X |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | We present a high resolution, ultra-frugal printing of paper microfluidic devices using in-house paraffin formulation on a simple filter paper. The patterns printed using an office inkjet printer formed a selective hydrophobic barrier of 4 ± 1 µm thickness with a hydrophilic channel width of 275 µm. These printed patterns effectively confine common aqueous solutions and solvents, which was verified by solvent compatibility studies. SEM analysis reveals that the solvent confinement is due to pore blockage in the filter paper. The fabricated paper-based device was validated for qualitative assessment of Candida albicans (pathogenic fungi) by using a combination of L-proline β-naphthylamide as the substrate and cinnamaldehyde as an indicator. Our studies reveal that the pathogenic fungi can be detected within 10 min with the limit of detection (LOD) of 0.86 × 10 6 cfu/mL. Owing to its simplicity, this facile method shows high potential and can be scaled up for developing robust paper-based devices for biomarker detection in resource-limited settings. Graphic abstract |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s10570-020-03314-3 |
| DOI: | 10.1007/s10570-020-03314-3.pdf |
| DOI: | 10.1007/s10570-020-03314-3/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s10570-020-03314-3 http://link.springer.com/content/pdf/10.1007/s10570-020-03314-3.pdf http://link.springer.com/article/10.1007/s10570-020-03314-3/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.54497B70 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10570-020-03314-3 |
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