Academic Journal
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin
| العنوان: | Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin |
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| المؤلفون: | Huang, Mou-Tuan, Ho, Chi-Tang, Wang, Zhi Yuan, Ferraro, Thomas, Finnegan-Olive, Tara, Lou, You-Rong, Mitchell, John M., Laskin, Jeffrey D., Newmark, Harold, Yang, Chung S., Conney, Allan H. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1992 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ORIGINAL ARTICLES |
| الوصف: | A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycydlic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[ a ]pyrene- and 7,12-dimethylbenz[ a ]- anthracene-induced tumor initiation as well as 12- O -tetra-decanoylpborbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with Individual polyphenolic compounds in green tea indicated that topical application of (—)-epigallocatechin gallate, (—)-epigallocatechin and (—)-epicatechin gallate Inhibited TPA-induced inflanunation in mouse epidermis. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://carcin.oxfordjournals.org/cgi/content/short/13/6/947; http://dx.doi.org/10.1093/carcin/13.6.947 |
| DOI: | 10.1093/carcin/13.6.947 |
| الاتاحة: | http://carcin.oxfordjournals.org/cgi/content/short/13/6/947 https://doi.org/10.1093/carcin/13.6.947 |
| Rights: | Copyright (C) 1992, Oxford University Press |
| رقم الانضمام: | edsbas.53FF679C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/carcin/13.6.947 |
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