التفاصيل البيبلوغرافية
| العنوان: |
A RETROSPECTIVE ANALYSIS OF GLUCORTICOSTEROIDS UTILIZATIONAMONG PATIENTS WITHRHEUMATOID ARTHRITIS |
| المؤلفون: |
Najlae El Ouardi, Laila Taoubane, Siham Sadni, Hajar El Hani, H. Julien Djossou, Mohamed Ahmed Ghassem, Abderrahim Majjad, Hamza Toufik, Asmaa Rezqi, Aziza Mounach, Lahsen Achemlal, Ahmed Bezza |
| بيانات النشر: |
Zenodo |
| سنة النشر: |
2022 |
| المجموعة: |
Zenodo |
| مصطلحات موضوعية: |
Cumulative Glucorticosteroids Dose Adverse Events Rheumatoid Arthritis |
| الوصف: |
Background: Glucocorticoid therapy is used widely in patients with rheumatoid arthritis(RA). Recently, treatment guidelines recommendglucorticosteroids (GCs) use in low dose and for a short time in RA.However, for many patients, it is still difficult to withdraw GCs once initiated. Objectives: to analyzeGCs utilization in RA patients and to evaluate the effects of increasing cumulativedoses on theprevalence of potential GCs related adverse events. Methods: we enrolled patients with RA. Corticoid exposure was defined: duration (short ≤6 months and long >6months), average daily dose (low ≤ 2.5mg, medium 2.5mg < ≤ 7.5mg and high > 7.5mg). Effect of increasing cumulative GCs doses on adverse events development were analyzed usingchi-square test or Fischers exact test. Regression models were used to identify the factors favoring GCs discontinuation. Results: a total of 168 RA were included (84 patients usedbDMARDs). The median of cumulative GCs dose was 14400mg. the majority of GCs users were prescribed high doseof GCs (54.3%) for a long duration (98.7%). Skin events (71.5%) were the majorside effects. Higher cumulative GCs doses compared with lower doses had increased incidence of diabetes, cardiovascular and ophthalmologic events (p=0.04, p=0.001, p=0.02 respectively).The prevalence of RA patients having withdrawnGCs was 38.7%. It was negatively associated in multivariable regression with RA duration (OR:0.8, IC95%:0.6-0.9). Surprisingly, there was no association in logistic regression with bDMARD use. Conclusions: GCs were used with high dose and for a long duration for the majority of our RA patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://doi.org/10.5281/zenodo.6831786; https://doi.org/10.5281/zenodo.6831787; oai:zenodo.org:6831787 |
| DOI: |
10.5281/zenodo.6831787 |
| الاتاحة: |
https://doi.org/10.5281/zenodo.6831787 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: |
edsbas.53D9A3D9 |
| قاعدة البيانات: |
BASE |