Academic Journal
Slipped capital femoral epiphyses: A major on‐target adverse event associated with FGFR tyrosine kinase inhibitors in pediatric patients
| العنوان: | Slipped capital femoral epiphyses: A major on‐target adverse event associated with FGFR tyrosine kinase inhibitors in pediatric patients |
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| المؤلفون: | Farouk Sait, Sameer, Fischer, Cheryl, Antal, Zoltan, Spatz, Krisoula, Prince, Daniel E., Ibanez, Katarzyna, Behr, Gerald G., Dunkel, Ira J., Karajannis, Matthias A. |
| المصدر: | Pediatric Blood & Cancer ; volume 70, issue 9 ; ISSN 1545-5009 1545-5017 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) are increasingly being used off label in pediatrics. Long‐term safety data are limited, and serious toxicities unique to pediatrics may emerge. In a retrospective analysis of patients less than 18 years of age with recurrent/refractory FGFR altered gliomas treated with FGFR TKIs at MSKCC ( n = 7), we observed slipped capital femoral epiphyses in three of seven patients along with increased linear growth velocity. Clinicians should closely monitor bone health and have a low index of suspicion for serious orthopedic complications including slipped capital femoral epiphyses and inform patients of related risks as part of consent when treating with FGFR TKIs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/pbc.30410 |
| الاتاحة: | http://dx.doi.org/10.1002/pbc.30410 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30410 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.539EBB0D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/pbc.30410 |
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