Academic Journal
Magnetic Resonance Microscopy Defines Ethanol-Induced Brain Abnormalities in Prenatal Mice: Effects of Acute Insult on Gestational Day 7
| العنوان: | Magnetic Resonance Microscopy Defines Ethanol-Induced Brain Abnormalities in Prenatal Mice: Effects of Acute Insult on Gestational Day 7 |
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| المؤلفون: | Godin, Elizabeth A., O'Leary-Moore, Shonagh K., Khan, Amber A., Parnell, Scott E., Ament, Jacob J., Dehart, Deborah B., Johnson, Brice W., Allan Johnson, G., Styner, Martin A., Sulik, Kathleen K. |
| المصدر: | Alcoholism - Clinical and Experimental Research, 34(1) |
| سنة النشر: | 2010 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Holoprosencephaly, Microscopy, Leptomeningeal Heterotopia, Ethanol, Acute, Nuclear magnetic resonance imaging, Alcoholic beverage, Nervous system diseases, Congenital disease, Cerebral disorder, Arhinencephaly, Malformation, Prenatal, Pregnancy, Central nervous system disease, Fetal Alcohol Spectrum Disorder, Cortical Dysplasia, Fetal alcohol syndrome, Dysplasia, Magnetic Resonance Microscopy, Mouse, Animal, Toxicity, Magnetic resonance, Encephalon |
| الوصف: | This magnetic resonance microscopy (MRM)-based report is the 2nd in a series designed to illustrate the spectrum of craniofacial and central nervous system (CNS) dysmorphia resulting from single- and multiple-day maternal ethanol treatment. The study described in this report examined the consequences of ethanol exposure on gestational day (GD) 7 in mice, a time in development when gastrulation and neural plate development begins; corresponding to the mid- to late 3rd week post-fertilization in humans. Acute GD 7 ethanol exposure in mice has previously been shown to result in CNS defects consistent with holoprosencephaly (HPE) and craniofacial anomalies typical of those in Fetal Alcohol Syndrome (FAS). MRM has facilitated further definition of the range of GD 7 ethanol-induced defects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://cdr.lib.unc.edu/downloads/v692td51k?file=thumbnail; https://cdr.lib.unc.edu/downloads/v692td51k |
| DOI: | 10.17615/fwq7-9q23 |
| الاتاحة: | https://doi.org/10.17615/fwq7-9q23 https://cdr.lib.unc.edu/downloads/v692td51k?file=thumbnail https://cdr.lib.unc.edu/downloads/v692td51k |
| Rights: | http://rightsstatements.org/vocab/InC/1.0/ |
| رقم الانضمام: | edsbas.5397627B |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/fwq7-9q23 |
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