Academic Journal
Graph-Based Analyses of Dynamic Water-Mediated Hydrogen-Bond Networks in Phosphatidylserine: Cholesterol Membranes
| العنوان: | Graph-Based Analyses of Dynamic Water-Mediated Hydrogen-Bond Networks in Phosphatidylserine: Cholesterol Membranes |
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| المؤلفون: | Jain, Honey, Karathanou, Konstantina, Bondar, Ana-Nicoleta |
| سنة النشر: | 2023 |
| المجموعة: | FU Berlin: Refubium |
| مصطلحات موضوعية: | depth-first-search algorithm, lipid-water hydrogen-bond network, hydrogen-bond network topology, POPS-cholesterol hydrogen-bond networks, ddc:530 |
| الوصف: | Phosphatidylserine lipids are anionic molecules present in eukaryotic plasma membranes, where they have essential physiological roles. The altered distribution of phosphatidylserine in cells such as apoptotic cancer cells, which, unlike healthy cells, expose phosphatidylserine, is of direct interest for the development of biomarkers. We present here applications of a recently implemented Depth-First-Search graph algorithm to dissect the dynamics of transient water-mediated lipid clusters at the interface of a model bilayer composed of 1-palmytoyl-2-oleoyl-sn-glycero-2-phosphatidylserine (POPS) and cholesterol. Relative to a reference POPS bilayer without cholesterol, in the POPS:cholesterol bilayer there is a somewhat less frequent sampling of relatively complex and extended water-mediated hydrogen-bond networks of POPS headgroups. The analysis protocol used here is more generally applicable to other lipid:cholesterol bilayers. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 14 Seiten; application/pdf |
| اللغة: | English |
| Relation: | https://refubium.fu-berlin.de/handle/fub188/40626; http://dx.doi.org/10.17169/refubium-40347 |
| DOI: | 10.17169/refubium-40347 |
| DOI: | 10.3390/biom13081238 |
| الاتاحة: | https://refubium.fu-berlin.de/handle/fub188/40626 https://doi.org/10.17169/refubium-40347 https://doi.org/10.3390/biom13081238 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5379B421 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17169/refubium-40347 |
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