Academic Journal
Safety and Immunogenicity of SARS-CoV-2 vaccines in people with HIV
| العنوان: | Safety and Immunogenicity of SARS-CoV-2 vaccines in people with HIV |
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| المؤلفون: | González de Aledo, Manuel, Cañizares, Angelina, Vázquez-Rodríguez, Pilar, Castro-Iglesias, Ángeles, Moldes, Luz, López, Soledad, Miguez, Enrique, Bou, Germán, Mena, Álvaro |
| بيانات النشر: | Wolters Kluwer |
| سنة النشر: | 2022 |
| المجموعة: | RUC - Repositorio Universidade Coruña |
| مصطلحات موضوعية: | Coronavirus disease 2019, HIV, mRNA vaccine, SARS-CoV-2 |
| الوصف: | Concise communication ; [Abstract] Objective: To evaluate the safety and the serological response after two doses of mRNA-based SARS-CoV-2 vaccination in people with HIV (PWH). Methods: Participants were evaluated 4 weeks after the second dose of mRNA-1273 or BNT162b2 vaccine. Tolerability was evaluated with a specific adverse event questionnaire. Patient's sera were analysed using LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin). Results: One-hundred PWH were included, 75% of them men, with a mean age of 44 ± 11 years old, all receiving antiretroviral treatment and mostly with controlled viral loads (98% with HIV RNA <50 copies/ml) and 96% had >200 CD4+/μl. All patients seroconverted after vaccination (antibody concentration ≥33.8 binding antibody units [BAU]/ml). Only 3% of the patients had a low antibody concentration (<520 BAU/ml), whereas 67% of them had concentrations above the assay's detection range (>2080 BAU/ml). Fifty-six patients had local or systemic symptoms, with mild arthromyalgia being the most common systemic symptom. No severe adverse events were reported. Conclusions: Vaccination with two doses of mRNA-1273 or BNT162b2 is well tolerated in PWH under effective antiretroviral treatment and it leads to a successful antibody response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1097/qad.0000000000003161; http://hdl.handle.net/2183/39592 |
| DOI: | 10.1097/QAD.0000000000003161 |
| الاتاحة: | http://hdl.handle.net/2183/39592 https://doi.org/10.1097/QAD.0000000000003161 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.534676A3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/QAD.0000000000003161 |
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