Academic Journal
Hepatitis B virus genotypes, core promoter variants, and precore stop codonvariants in patients infected chronically in North-Eastern Italy.
| العنوان: | Hepatitis B virus genotypes, core promoter variants, and precore stop codonvariants in patients infected chronically in North-Eastern Italy. |
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| المؤلفون: | DAL MOLIN G, POLI A, BIAGI C, CROCE', Saveria, Lory, D'AGARO, PIERLANFRANCO, COMAR, Manola, TIRIBELLI, CLAUDIO, CAMPELLO, CESARE |
| المساهمون: | DAL MOLIN, G, Poli, A, Croce', Saveria, D'Agaro, Pierlanfranco, Biagi, C, Comar, Manola, Tiribelli, Claudio, Campello, Cesare |
| سنة النشر: | 2006 |
| المجموعة: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| مصطلحات موضوعية: | Core promoter variants, Genotypes, HBV, Molecular epidemiology, Precore variants |
| الوصف: | The hepatitis B virus (HBV) genotypes distribution and the core promoter (CP)/precore (PC) variability were evaluated by a line probe assay in 272 patients infected chronically enrolled consecutively in an area of the North-Eastern Italy. Seven out of the eight genotypes were detected. Italian subjects (83% of the sample) were infected mainly by genotype D (73%) and A (26%); genotype F, and genotype H, were detected only in one subject. In foreigners, the genotype distribution reflected the distribution described for the areas of origin, that is, in Asia genotypes B, C, and D; in Africa genotypes A and E. CP and PC variants prevalence rates were 51% and 60%, respectively, and were significantly higher in Italian patients, probably in relation to their older age. In the analysis restricted to genotypes A and D, PC wild type was linked strongly to genotype A (OR = 4.08,95% CI = 3.07-5.43, P < 0.0001). In genotype A-infected patients, only e seroconversion was associated significantly with CP variants. In genotype D-infected subjects, CP variants were linked significantly to older age and to a higher e seroconversion rate, while PC variants also showed a strong relationship with an ALT lower activity and a lower viral load. In multivariate analysis, HBeAg positivity was associated strongly and independently with younger age, genotype A and CP wild type. Independent determinants of higher viral loads were recognized by increasing age, in male gender and concomitant presence of HBeAg and the CP wild type virus. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/16628589; info:eu-repo/semantics/altIdentifier/wos/WOS:000237371300005; volume:78; issue:6; firstpage:734; lastpage:740; numberofpages:7; journal:JOURNAL OF MEDICAL VIROLOGY; http://hdl.handle.net/11368/1749986; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33646486260 |
| DOI: | 10.1002/jmv.20616 |
| الاتاحة: | http://hdl.handle.net/11368/1749986 https://doi.org/10.1002/jmv.20616 |
| رقم الانضمام: | edsbas.53218CE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jmv.20616 |
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